Shareholder Breakdown
Shareholder Holders Values ($) % O/S Shares
Institution 199 661 92.99 32,521,761
Mutual Fund 208 323 45.14 15,788,266
Institutional Shareholder Rotation
Shareholder Holders Values Change ($) % O/S Shares Change
Buyers 85 71.04 9.91 3,467,499
Sellers 89 -68.21 9.03 -3,159,587
Net -- 2.83 0.88 307,912
Institutional Shareholder Concentration
Shareholder Values ($) % O/S Shares
Top 10 Inst. 412 58.31 20,392,665
Top 20 Inst. 526.26 74.33 25,994,477
Top 50 Inst. 614.17 86.61 30,291,677
Total Inst. 614.17 86.61 30,291,677
Institutional Shareholder Style
Shareholder Holders Values ($) % O/S Shares
Index 23 114 18.98 5,564,000
Growth 8 63 10.58 3,101,671
CoreGrowth 34 32 5.26 1,541,634
AggresGr 3 1 0.13 37,335
IncomeValue 4 14 2.42 708,091
Yield 3 1 0.12 34,519
GARP 21 183 30.55 8,955,081
HedgeFund 26 105 17.47 5,120,266
BrokerDealer 14 7 1.19 348,571
Specialty 1 0 0.00 501
CoreValue 20 21 3.49 1,022,313
DeepValue 5 3 0.58 169,045
Top Holders: Institutional Investor
Holder Shares Held % O/S Shares Change Filing Date
Fidelity Management & Research Company 5,225,358 14.94 249,531 12/31/2016
OppenheimerFunds, Inc. 3,037,007 8.68 36,187 12/31/2016
BlackRock Institutional Trust Company, N.A. 2,324,146 6.65 229,510 12/31/2016
Bellevue Asset Management AG 2,003,000 5.73 465,000 12/31/2016
Johnson & Johnson 1,923,077 5.50 0 03/29/2016
Blue Ridge Capital, L.L.C. 1,360,000 3.89 0 12/31/2016
The Vanguard Group, Inc. 1,308,184 3.74 10,025 12/31/2016
Point72 Asset Management, L.P. 1,213,117 3.47 -600,183 12/31/2016
Interwest Venture Management Co 1,074,316 3.07 1,074,316 12/31/2016
Koenig (Scott) 924,460 2.64 79,898 01/17/2017
Emerald Advisers, Inc. 840,996 2.40 72,893 12/31/2016
State Street Global Advisors (US) 839,491 2.40 8,661 12/31/2016
Eventide Asset Management, LLC 725,800 2.08 0 12/31/2016
Pinnacle Associates Ltd. 652,777 1.87 -45,363 12/31/2016
Franklin Advisers, Inc. 587,100 1.68 -11,700 12/31/2016
Hood River Capital Management LLC 480,452 1.37 291,278 12/31/2016
Spark Investment Management LLC 415,300 1.19 24,700 12/31/2016
Baker Bros. Advisors LP 363,676 1.04 0 12/31/2016
Northern Trust Investments, Inc. 349,067 1.00 3,323 12/31/2016
UBS Asset Management (Switzerland) 347,153 0.99 -86,463 12/31/2016
TIAA Global Asset Management 336,714 0.96 -6,445 12/31/2016
Voya Investment Management LLC 336,697 0.96 -5,012 12/31/2016
Geode Capital Management, L.L.C. 249,687 0.71 24,546 12/31/2016
Tiger Management L.L.C. 239,667 0.69 -26,400 12/31/2016
Rock Springs Capital Management LP 225,000 0.64 0 12/31/2016
Artal International S.C.A. 200,000 0.57 50,000 12/31/2016
Jennison Associates LLC 188,908 0.54 -6,203 12/31/2016
Marshall Wace LLP 181,267 0.52 85,551 12/31/2016
Federated Global Investment Management Corp. 179,924 0.51 -77,376 12/31/2016
First Eagle Investment Management, L.L.C. 175,000 0.50 -46,800 12/31/2016
Opaleye Management Inc. 170,000 0.49 25,000 12/31/2016
Rhenman & Partners Asset Management AB 155,000 0.44 15,000 12/31/2016
Millennium Management LLC 126,235 0.36 -64,317 12/31/2016
BlackRock Investment Management, LLC 124,466 0.36 -430 12/31/2016
Citadel LLC 121,278 0.35 107,610 12/31/2016
Principal Global Investors (Equity) 115,042 0.33 657 12/31/2016
Charles Schwab Investment Management, Inc. 114,861 0.33 -5,654 12/31/2016
Karrels (James) 105,331 0.30 5,000 01/25/2017
Morgan Stanley & Co. LLC 92,986 0.27 85,480 12/31/2016
BNY Mellon Asset Management 91,758 0.26 322 12/31/2016
Dafna Capital Management, LLC 89,200 0.26 35,000 12/31/2016
Bonvini Ezio 86,781 0.25 10,698 10/19/2016
UBS Asset Management (Americas), Inc. 86,701 0.25 -5,354 12/31/2016
Sphera Funds Management Ltd. 81,200 0.23 -48,800 12/31/2016
Numeric Investors LLC 76,465 0.22 17,600 12/31/2016
TFS Capital LLC 74,801 0.21 74,801 12/31/2016
Citi Investment Research (US) 70,498 0.20 60,312 12/31/2016
Arrowstreet Capital, Limited Partnership 68,647 0.20 -25,821 12/31/2016
Allianz Global Investors U.S. LLC 67,337 0.19 -45,341 12/31/2016
California State Teachers Retirement System 65,749 0.19 -1,700 12/31/2016

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