Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 231 1,236.18 96.51 59,117,304
Mutual Fund 267 444.79 34.78 21,265,578
Insider 7 49.11 2.60 1,595,102

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 91 126.85 9.89 6,057,222
Sellers 141 -225.39 15.64 -9,578,761
Net -98.54 5.75 -3,521,539

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 1,285.29 99.11 60,712,406
Top 10 Inst. 821.04 64.01 39,209,156
Top 20 Inst. 1,015.68 78.19 47,897,848
Top 50 Inst. 1,198.21 92.48 56,650,263

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 52 279.49 21.79 13,347,719
Aggressive Growth 2 1.73 0.13 82,433
Core Growth 40 81.62 6.36 3,898,460
Growth 10 196.14 15.29 9,366,826
Income 3 3.37 0.26 160,876
Income Value 1 2.98 0.23 142,419
Yield 2 0.39 0.03 18,457
Index 30 302.51 23.68 14,504,133
Other 75 574.15 44.76 27,417,793
Broker Dealer 20 15.59 1.22 744,701
GARP 22 154.79 12.07 7,392,755
Hedge Fund 32 358.78 27.97 17,132,277
Specialty -- --
VC Private Equity 1 44.98 3.51 2,148,060
Value 36 59.07 4.65 2,845,749
Core Value 29 28.17 2.23 1,368,152
Deep Value 7 30.89 2.41 1,477,597

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 8,544,597 13.95 1,168,571 9/30/21
RA Capital Management, LP 5,943,594 9.70 -- 9/30/21
Wasatch Global Investors Inc 4,319,051 7.05 201,534 9/30/21
BlackRock Institutional Trust Company, N.A. 4,257,194 6.95 -139,578 9/30/21
RTW Investments L.P. 3,975,554 6.49 1,428,629 9/30/21
The Vanguard Group, Inc. 3,896,140 6.36 -44,924 9/30/21
State Street Global Advisors (US) 2,942,781 4.80 -288,778 9/30/21
Perceptive Advisors LLC 2,148,060 3.51 -- 9/30/21
Victory Capital Management Inc. 1,965,101 3.21 315,629 9/30/21
Dimensional Fund Advisors, L.P. 1,217,084 1.99 -61,220 9/30/21
Koenig (Scott) 1,164,150 1.90 -- 3/19/21
Geode Capital Management, L.L.C. 1,042,005 1.70 -4,746 9/30/21
Great Point Partners, LLC 1,000,000 1.63 -378,495 9/30/21
Fidelity Management & Research Company LLC 906,225 1.48 -229,625 9/30/21
Point72 Asset Management, L.P. 883,461 1.44 470,361 9/30/21
Citadel Advisors LLC 874,033 1.43 86,255 9/30/21
Woodline Partners LP 825,669 1.35 580,073 9/30/21
Fidelity Institutional Asset Management 742,810 1.21 -25,211 9/30/21
Rock Springs Capital Management LP 641,816 1.05 186,000 9/30/21
Candriam Belgium S.A. 608,523 0.99 -- 9/30/21
Northern Trust Investments, Inc. 553,072 0.90 -12,631 9/30/21
Rhenman & Partners Asset Management AB 545,160 0.89 -- 9/30/21
Millennium Management LLC 512,049 0.84 29,720 9/30/21
Wellington Management Company, LLP 469,162 0.77 -1,970 10/31/21
Opaleye Management Inc. 462,000 0.75 -116,150 9/30/21
Charles Schwab Investment Management, Inc. 450,030 0.73 -454 9/30/21
Baker Bros. Advisors LP 442,579 0.72 241,900 9/30/21
Macquarie Investment Management 420,000 0.69 -- 9/30/21
BlackRock Financial Management, Inc. 418,505 0.68 -63,028 9/30/21
Pinnacle Associates Ltd. 416,558 0.68 -5,735 9/30/21
BlackRock Asset Management Ireland Limited 381,075 0.62 19,655 9/30/21
BlackRock Advisors (UK) Limited 374,547 0.61 -6,491 11/30/21
Ally Bridge Group NY LLC 365,000 0.60 252,161 9/30/21
Nuveen LLC 351,760 0.57 -7,315 9/30/21
Lord, Abbett & Co. LLC 281,307 0.46 -3,674 9/30/21
Principal Global Investors (Equity) 256,838 0.42 7,582 9/30/21
Goldman Sachs & Company, Inc. 246,896 0.40 58,366 9/30/21
Granahan Investment Management, Inc. 231,058 0.38 -28,384 9/30/21
Ikarian Capital LLC 188,478 0.31 -271,124 9/30/21
BlackRock Investment Management, LLC 170,982 0.28 -18,809 9/30/21
Integral Health Asset Management, LLC 160,000 0.26 160,000 9/30/21
Karrels (James) 143,460 0.23 -15,000 3/22/21
BNY Mellon Asset Management 142,419 0.23 7,672 9/30/21
Citi Investment Research (US) 141,122 0.23 -49,457 9/30/21
Bonvini Ezio 118,640 0.19 2,540 11/16/21
Schweizerische Nationalbank 106,100 0.17 6,900 9/30/21
PanAgora Asset Management Inc. 106,047 0.17 -125,003 9/30/21
Rafferty Asset Management LLC 103,931 0.17 -18,360 9/30/21
BlackRock Investment Management (UK) Ltd. 100,332 0.16 -1,274 9/30/21
HRT Financial LP 93,308 0.15 93,308 9/30/21

* Insider values reflect direct beneficial ownership.

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