Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 188 900.75 108.07 52,837,257
Mutual Fund 407 469.64 57.97 28,281,425
Insider 11 28.06 3.19 1,559,187

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 96 211.20 25.45 12,445,472
Sellers 110 -178.28 21.02 -10,278,571
Net 32.92 4.43 2,166,901

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 873.08 106.07 51,863,458
Top 10 Inst. 470.67 57.72 28,219,086
Top 20 Inst. 637.40 77.68 37,979,918
Top 50 Inst. 807.42 98.23 48,030,061

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 44 166.14 19.94 9,749,336
Aggressive Growth 2 0.65 0.08 38,446
Core Growth 30 76.72 9.25 4,522,642
Growth 12 88.77 10.61 5,188,248
Income 6 3.98 0.48 235,812
Income Value 2 2.14 0.26 126,057
Yield 4 1.84 0.22 109,755
Index 23 200.31 24.25 11,855,124
Other 68 456.89 54.55 26,672,597
Broker Dealer 15 7.11 0.86 419,252
GARP 23 290.39 34.46 16,846,851
Hedge Fund 26 128.90 15.56 7,609,650
Specialty 1 0.69 0.08 40,512
VC Private Equity 3 29.80 3.59 1,756,332
Value 23 64.81 7.81 3,819,029
Core Value 19 59.65 7.19 3,514,901
Deep Value 4 5.16 0.62 304,128

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Invesco Advisers, Inc. 4,468,090 9.14 4,379,070 6/30/19
Bellevue Asset Management AG 4,395,264 8.99 204,959 6/30/19
BlackRock Institutional Trust Company, N.A. 3,567,837 7.30 511,437 6/30/19
The Vanguard Group, Inc. 3,198,214 6.54 161,920 6/30/19
Millennium Management LLC 2,946,050 6.03 143,578 6/30/19
State Street Global Advisors (US) 2,623,875 5.37 1,200,157 6/30/19
Columbia Wanger Asset Management, LLC 2,258,989 4.62 1,943,018 6/30/19
Johnson & Johnson 1,923,077 3.93 -- 12/31/18
Wasatch Advisors, Inc. 1,422,245 2.91 130,732 6/30/19
Hood River Capital Management LLC 1,415,445 2.90 -27,751 6/30/19
Fidelity Management & Research Company 1,282,543 2.62 -275,188 6/30/19
Dimensional Fund Advisors, L.P. 1,262,543 2.58 128,786 6/30/19
Koenig (Scott) 1,084,255 2.22 -- 3/22/19
InterWest Partners 1,074,316 2.20 -- 6/30/19
GMT Capital Corp. 1,049,100 2.15 793,900 6/30/19
Rhenman & Partners Asset Management AB 857,169 1.75 -110,017 6/30/19
Federated Global Investment Management Corp. 849,807 1.74 -250,881 6/30/19
Nuveen LLC 799,123 1.63 201,802 6/30/19
Candriam Luxembourg S.A. 750,988 1.54 85,500 6/30/19
Candriam Belgium S.A. 750,988 1.54 -- 6/30/19
Lord, Abbett & Co. LLC 741,191 1.52 97,321 6/30/19
UBS Asset Management (Switzerland) 698,966 1.43 240,844 6/30/19
Geode Capital Management, L.L.C. 598,129 1.22 90,465 6/30/19
Pinnacle Associates Ltd. 576,465 1.18 -48,683 6/30/19
Sofinnova Investments, Inc 550,443 1.13 26,687 6/30/19
683 Capital Management LLC 534,970 1.09 50,000 6/30/19
Northern Trust Investments, Inc. 504,754 1.03 6,353 6/30/19
Eventide Asset Management, LLC 485,000 0.99 -- 6/30/19
Point72 Asset Management, L.P. 445,572 0.91 -1,105,677 6/30/19
Renaissance Technologies LLC 424,423 0.87 -399,300 6/30/19
Numeric Investors LLC 333,460 0.68 70,874 6/30/19
BlackRock Advisors (UK) Limited 319,370 0.65 7,215 7/31/19
BlackRock Asset Management Ireland Limited 318,953 0.65 305,333 6/30/19
PanAgora Asset Management Inc. 300,587 0.61 300,587 6/30/19
Rock Springs Capital Management LP 300,000 0.61 -- 6/30/19
D. E. Shaw & Co., L.P. 298,438 0.61 -374,805 6/30/19
Macquarie Investment Management 275,000 0.56 15,000 6/30/19
Charles Schwab Investment Management, Inc. 262,919 0.54 23,779 6/30/19
BlackRock Financial Management, Inc. 240,646 0.49 105,342 6/30/19
Principal Global Investors (Equity) 234,832 0.48 51,952 6/30/19
Granahan Investment Management, Inc. 214,415 0.44 -13,304 6/30/19
Eversept Partners, LP 190,623 0.39 190,623 6/30/19
AXA Rosenberg Investment Management LLC 178,400 0.36 110,026 6/30/19
BlackRock Investment Management, LLC 174,647 0.36 37,024 6/30/19
Bonvini Ezio 154,208 0.32 -- 3/22/19
Medical Strategy GmbH 149,055 0.30 -- 6/30/19
Rafferty Asset Management LLC 142,918 0.29 93,157 6/30/19
Karrels (James) 135,487 0.28 -- 3/22/19
Allianz Global Investors U.S. LLC 134,699 0.28 -4,830 6/30/19
Fosun International Ltd 131,573 0.27 54,000 6/30/19

* Insider values reflect direct beneficial ownership.

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