Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 223 550.38 100.31 61,527,134
Mutual Fund 256 182.21 32.08 19,668,380
Insider 6 8.18 2.63 1,613,142

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 109 80.33 14.92 9,148,035
Sellers 113 -98.13 14.38 -8,817,301
Net -17.80 0.54 330,734

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 558.69 102.97 63,157,434
Top 10 Inst. 362.54 67.09 41,151,027
Top 20 Inst. 430.84 80.75 49,525,752
Top 50 Inst. 514.27 95.17 58,373,777

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 52 92.73 17.03 10,445,757
Aggressive Growth 3 1.85 0.34 210,009
Core Growth 38 19.84 3.56 2,180,884
Growth 11 71.03 13.13 8,054,864
Income 4 1.39 0.26 157,376
Income Value 1 1.22 0.23 138,856
Yield 3 0.16 0.03 18,520
Index 32 142.80 26.37 16,172,362
Other 75 281.17 52.03 31,912,631
Broker Dealer 19 14.76 2.73 1,675,829
GARP 21 57.97 10.72 6,576,932
Hedge Fund 33 194.58 36.01 22,086,641
Specialty 1 0.12 0.02 13,440
VC Private Equity 1 13.74 2.54 1,559,789
Value 30 29.50 4.11 2,521,295
Core Value 24 17.17 1.83 1,122,057
Deep Value 6 12.33 2.28 1,399,238

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 7,325,514 11.94 -1,234,948 3/31/22
RA Capital Management, LP 6,103,594 9.95 -- 3/31/22
Armistice Capital LLC 5,000,000 8.15 2,300,000 3/31/22
BlackRock Institutional Trust Company, N.A. 4,050,139 6.60 -54,603 3/31/22
Wasatch Global Investors Inc 4,041,339 6.59 -67,362 3/31/22
The Vanguard Group, Inc. 4,032,239 6.57 86,061 3/31/22
RTW Investments L.P. 3,975,554 6.48 -- 3/31/22
State Street Global Advisors (US) 3,544,724 5.78 632,054 3/31/22
Perceptive Advisors LLC 1,559,789 2.54 -105,454 3/31/22
Millennium Management LLC 1,518,135 2.48 488,599 3/31/22
Assenagon Asset Management S.A. 1,253,659 2.04 1,079,273 3/31/22
Koenig (Scott) 1,217,415 1.98 53,265 5/16/22
Dimensional Fund Advisors, L.P. 1,160,352 1.89 -75,524 3/31/22
Geode Capital Management, L.L.C. 989,539 1.61 -29,222 3/31/22
Rock Springs Capital Management LP 932,728 1.52 75,523 3/31/22
Two Sigma Investments, LP 606,794 0.99 557,946 3/31/22
Morgan Stanley & Co. LLC 600,936 0.98 367,125 3/31/22
Renaissance Technologies LLC 585,712 0.96 585,712 3/31/22
Candriam Belgium S.A. 517,592 0.84 -30,137 3/31/22
Northern Trust Investments, Inc. 509,998 0.83 -31,411 3/31/22
Fidelity Management & Research Company LLC 486,322 0.79 -89,699 3/31/22
Charles Schwab Investment Management, Inc. 470,970 0.77 14,776 3/31/22
BlackRock Financial Management, Inc. 457,997 0.75 45,875 3/31/22
Baker Bros. Advisors LP 442,579 0.72 -- 3/31/22
Macquarie Investment Management 420,000 0.68 -- 3/31/22
Wellington Management Company, LLP 409,487 0.67 5,150 8/31/21
Pinnacle Associates Ltd. 403,616 0.66 -14,775 3/31/22
Fidelity Institutional Asset Management 387,366 0.63 -287,094 3/31/22
Opaleye Management Inc. 376,400 0.61 -85,600 3/31/22
BlackRock Advisors (UK) Limited 355,068 0.58 7,716 4/30/22
BlackRock Asset Management Ireland Limited 343,474 0.56 -30,428 3/31/22
Nuveen LLC 303,754 0.50 -38,731 3/31/22
Federated Hermes MDTA LLC 290,458 0.47 290,458 3/31/22
Rhenman & Partners Asset Management AB 287,081 0.47 -13,572 3/31/22
Goldman Sachs & Company, Inc. 279,552 0.46 -41,226 3/31/22
Principal Global Investors (Equity) 269,274 0.44 9,995 3/31/22
Woodline Partners LP 269,272 0.44 -- 3/31/22
Sessa Capital 244,864 0.40 244,864 3/31/22
PanAgora Asset Management Inc. 244,224 0.40 80,604 3/31/22
D. E. Shaw & Co., L.P. 240,598 0.39 181,203 3/31/22
BofA Global Research (US) 221,792 0.36 103,359 3/31/22
Walleye Capital LLC 213,978 0.35 213,978 3/31/22
Rafferty Asset Management LLC 207,643 0.34 35,864 3/31/22
J.P. Morgan Securities LLC 192,069 0.31 192,069 3/31/22
Dafna Capital Management, LLC 192,000 0.31 102,000 3/31/22
AXA Investment Managers UK Ltd. 186,900 0.30 186,900 3/31/22
Jacobs Levy Equity Management, Inc. 168,224 0.27 168,224 3/31/22
BlackRock Investment Management, LLC 165,913 0.27 -1,827 3/31/22
Ikarian Capital LLC 164,119 0.27 8,072 3/31/22
Tudor Investment Corporation 153,031 0.25 100,861 3/31/22

* Insider values reflect direct beneficial ownership.

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