Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	205	1,373.83	97.26	54,661,082
Mutual Fund	284	452.97	33.08	18,460,311
Insider	10	12.79	2.85	1,603,749

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	104	115.91	8.23	4,625,591
Sellers	110	-216.54	14.43	-8,107,727
Net		-100.63	6.20	-3,482,136

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	1,386.62	100.11	56,264,831
Top 10 Inst.	877.75	62.00	34,845,066
Top 20 Inst.	1,107.03	79.78	44,842,338
Top 50 Inst.	1,309.44	94.40	53,056,683

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	54	256.84	18.17	10,211,949
Aggressive Growth	3	1.55	0.11	61,696
Core Growth	40	103.43	7.32	4,116,667
Growth	11	151.86	10.74	6,033,586
Income	5	3.89	0.28	158,855
Income Value	1	3.29	0.23	130,575
Yield	4	0.60	0.05	28,280
Index	27	309.47	22.01	12,369,519
Other	67	772.62	54.57	30,671,282
Broker Dealer	18	13.10	0.93	520,199
GARP	20	250.23	17.67	9,933,672
Hedge Fund	28	476.76	33.67	18,926,230
Specialty	--	--	--	--
VC Private Equity	1	32.52	2.30	1,291,181
Value	25	19.10	1.35	760,731
Core Value	21	12.33	0.88	492,119
Deep Value	4	6.77	0.48	268,612

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Bellevue Asset Management AG	5,282,188	9.40	280,072	9/30/20
Invesco Advisers, Inc.	4,451,810	7.92	-1,884	9/30/20
RA Capital Management, LP	4,375,217	7.78	-209,435	9/30/20
BlackRock Institutional Trust Company, N.A.	3,839,080	6.83	154,665	9/30/20
Consonance Capital Management LP	3,747,298	6.67	-294,237	9/30/20
Point72 Asset Management, L.P.	3,595,079	6.40	915,176	9/30/20
The Vanguard Group, Inc.	3,300,787	5.87	18,903	9/30/20
Wasatch Global Investors Inc	2,433,724	4.33	122,142	9/30/20
State Street Global Advisors (US)	2,309,668	4.11	740,388	9/30/20
Great Point Partners, LLC	1,510,215	2.69	10,215	9/30/20
Dimensional Fund Advisors, L.P.	1,360,785	2.42	-6,541	9/30/20
Perceptive Advisors LLC	1,291,181	2.30	3,167	9/30/20
RTW Investments L.P.	1,255,299	2.23	9,483	9/30/20
Fidelity Management & Research Company LLC	1,169,553	2.08	686,201	9/30/20
Koenig (Scott)	1,164,150	2.07	79,895	3/20/20
Nuveen LLC	891,967	1.59	127,172	9/30/20
Geode Capital Management, L.L.C.	785,369	1.40	39,763	9/30/20
D. E. Shaw & Co., L.P.	729,464	1.30	-125,188	9/30/20
Hood River Capital Management LLC	678,178	1.21	-70,740	9/30/20
Millennium Management LLC	671,326	1.19	-511,495	9/30/20
Rhenman & Partners Asset Management AB	635,711	1.13	-39,289	9/30/20
Northern Trust Investments, Inc.	587,109	1.04	16,481	9/30/20
Candriam Belgium S.A.	581,854	1.04	113,421	9/30/20
Citadel Advisors LLC	572,575	1.02	250,096	9/30/20
Opaleye Management Inc.	527,000	0.94	26,000	9/30/20
Pinnacle Associates Ltd.	427,396	0.76	-95,910	9/30/20
Macquarie Investment Management	420,000	0.75	--	9/30/20
BlackRock Financial Management, Inc.	379,577	0.68	110,708	9/30/20
Two Sigma Investments, LP	368,926	0.66	-6,376	9/30/20
Charles Schwab Investment Management, Inc.	350,075	0.62	27,210	9/30/20
BlackRock Advisors (UK) Limited	269,413	0.48	18,427	10/31/20
Rock Springs Capital Management LP	262,641	0.47	28,125	9/30/20
BlackRock Asset Management Ireland Limited	256,327	0.46	37,764	9/30/20
BlackRock Investment Management, LLC	204,729	0.36	5,449	9/30/20
PanAgora Asset Management Inc.	204,618	0.36	17,488	9/30/20
Atika Capital Management LLC	203,000	0.36	1,000	9/30/20
Principal Global Investors (Equity)	189,487	0.34	6,881	9/30/20
Granahan Investment Management, Inc.	183,875	0.33	-35,231	9/30/20
Arrowstreet Capital, Limited Partnership	180,658	0.32	-217,680	9/30/20
Wellington Management Company, LLP	170,541	0.30	-5,075	9/30/20
Goldman Sachs & Company, Inc.	162,307	0.29	-73,084	9/30/20
Karrels (James)	152,460	0.27	4,473	3/20/20
BofA Global Research (US)	144,112	0.26	20,046	9/30/20
BNY Mellon Asset Management	130,575	0.23	2,508	9/30/20
Goldman Sachs Asset Management (US)	121,410	0.22	-20,810	9/30/20
California Public Employees' Retirement System	119,488	0.21	22,488	9/30/20
MFS Investment Management	113,950	0.20	-36,220	9/30/20
Schweizerische Nationalbank	105,800	0.19	1,900	9/30/20
Endurant Capital Management LP	97,374	0.17	97,374	9/30/20
Bonvini Ezio	91,357	0.16	-62,851	9/18/20

* Insider values reflect direct beneficial ownership.