Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 221 1,254.98 97.16 54,697,312
Mutual Fund 286 432.96 30.97 17,396,394
Insider 7 49.81 2.63 1,563,902

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 119 153.33 11.13 6,674,791
Sellers 85 -173.59 12.53 -7,514,082
Net -20.26 1.40 -839,291

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 1,304.79 99.80 56,261,214
Top 10 Inst. 747.50 58.12 32,699,004
Top 20 Inst. 997.45 76.62 43,174,967
Top 50 Inst. 1,212.49 92.94 52,379,395

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 53 212.85 16.56 9,316,674
Aggressive Growth 2 0.92 0.07 40,201
Core Growth 42 58.46 4.56 2,563,089
Growth 9 153.47 11.93 6,713,384
Income 5 3.93 0.30 167,999
Income Value 1 3.20 0.25 139,798
Yield 4 0.74 0.05 28,201
Index 33 344.32 26.39 14,877,377
Other 70 658.33 51.15 28,780,294
Broker Dealer 20 19.54 1.52 853,338
GARP 21 229.27 17.83 10,028,847
Hedge Fund 26 368.85 28.68 16,135,887
Specialty 1 1.35 0.07 42,355
VC Private Equity 2 39.32 3.06 1,719,867
Value 31 22.92 1.78 1,003,154
Core Value 27 16.49 1.28 722,240
Deep Value 4 6.43 0.50 280,914

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 5,904,517 10.50 622,329 12/31/20
RA Capital Management, LP 4,375,217 7.78 -- 12/31/20
BlackRock Institutional Trust Company, N.A. 4,176,444 7.42 337,364 12/31/20
Wasatch Global Investors Inc 3,672,416 6.53 1,238,692 12/31/20
The Vanguard Group, Inc. 3,575,584 6.36 274,797 12/31/20
Invesco Advisers, Inc. 3,016,240 5.36 -1,435,570 12/31/20
State Street Global Advisors (US) 2,577,363 4.58 267,695 12/31/20
Consonance Capital Management LP 2,299,829 4.09 -1,447,469 12/31/20
Citadel Advisors LLC 1,641,261 2.92 1,068,686 12/31/20
Point72 Asset Management, L.P. 1,460,133 2.60 -2,134,946 12/31/20
Perceptive Advisors LLC 1,261,060 2.24 -30,121 12/31/20
RTW Investments L.P. 1,256,409 2.23 1,110 12/31/20
Great Point Partners, LLC 1,239,287 2.20 -270,928 12/31/20
Dimensional Fund Advisors, L.P. 1,224,848 2.18 -135,937 12/31/20
Fidelity Management & Research Company LLC 1,205,850 2.14 36,297 12/31/20
Koenig (Scott) 1,164,150 1.94 -- 3/19/21
Geode Capital Management, L.L.C. 884,669 1.57 99,300 12/31/20
Nuveen LLC 873,221 1.55 -18,746 12/31/20
Hood River Capital Management LLC 690,344 1.23 12,166 12/31/20
Candriam Belgium S.A. 676,125 1.20 94,271 12/31/20
Rhenman & Partners Asset Management AB 625,000 1.11 -10,711 12/31/20
Northern Trust Investments, Inc. 583,856 1.04 -3,253 12/31/20
Millennium Management LLC 580,580 1.03 -90,746 12/31/20
D. E. Shaw & Co., L.P. 567,404 1.01 -162,060 12/31/20
Sofinnova Investments, Inc 458,807 0.82 458,807 12/31/20
Two Sigma Investments, LP 453,568 0.81 84,642 12/31/20
Macquarie Investment Management 420,000 0.75 -- 12/31/20
Charles Schwab Investment Management, Inc. 394,200 0.70 44,125 12/31/20
BlackRock Financial Management, Inc. 378,506 0.67 -1,071 12/31/20
BlackRock Advisors (UK) Limited 372,022 0.62 -833 3/31/21
Opaleye Management Inc. 370,600 0.66 -156,400 12/31/20
Goldman Sachs & Company, Inc. 364,171 0.65 201,864 12/31/20
Pinnacle Associates Ltd. 341,846 0.61 -85,550 12/31/20
PanAgora Asset Management Inc. 317,606 0.56 112,988 12/31/20
Rock Springs Capital Management LP 309,510 0.55 46,869 12/31/20
BlackRock Asset Management Ireland Limited 291,482 0.52 35,155 12/31/20
Granahan Investment Management, Inc. 289,861 0.52 105,986 12/31/20
Arrowstreet Capital, Limited Partnership 269,328 0.48 88,670 12/31/20
Baker Bros. Advisors LP 200,679 0.36 200,679 12/31/20
Principal Global Investors (Equity) 200,008 0.36 10,521 12/31/20
BlackRock Investment Management, LLC 192,121 0.34 -12,608 12/31/20
Atom Investors LP 157,452 0.28 114,723 12/31/20
BofA Global Research (US) 149,923 0.27 5,811 12/31/20
Wellington Management Company, LLP 149,796 0.27 -20,745 12/31/20
Karrels (James) 143,460 0.26 -15,000 3/22/21
BNY Mellon Asset Management 139,798 0.25 9,223 12/31/20
Tudor Investment Corporation 136,085 0.24 136,085 12/31/20
California Public Employees' Retirement System 117,741 0.21 -1,747 12/31/20
Schweizerische Nationalbank 116,200 0.21 10,400 12/31/20
MFS Investment Management 112,818 0.20 -1,132 12/31/20

* Insider values reflect direct beneficial ownership.

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