Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	208	1,492.06	98.72	53,426,263
Mutual Fund	284	430.49	32.76	17,369,127
Insider	10	13.30	2.96	1,603,749

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	110	482.94	32.03	17,332,228
Sellers	110	-310.85	23.30	-12,609,521
Net		172.09	8.73	4,722,707

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	1,529.82	105.25	56,956,904
Top 10 Inst.	909.68	61.96	33,532,138
Top 20 Inst.	1,187.22	82.03	44,394,236
Top 50 Inst.	1,437.80	98.82	53,480,827

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	54	284.74	18.88	10,216,779
Aggressive Growth	3	8.01	0.53	286,919
Core Growth	40	116.23	7.71	4,173,976
Growth	11	160.50	10.64	5,755,884
Income	4	3.65	0.25	135,426
Income Value	1	3.58	0.24	128,067
Yield	3	0.07	0.01	7,359
Index	26	317.72	21.01	11,371,269
Other	72	851.84	56.27	30,453,805
Broker Dealer	19	17.60	1.16	629,277
GARP	19	248.40	16.44	8,899,302
Hedge Fund	32	549.21	36.24	19,613,484
Specialty	1	0.66	0.04	23,728
VC Private Equity	1	35.96	2.38	1,288,014
Value	26	24.92	1.67	902,838
Core Value	22	14.43	0.97	526,700
Deep Value	4	10.49	0.70	376,138

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Bellevue Asset Management AG	5,002,116	9.24	-1,117,034	6/30/20
RA Capital Management, LP	4,584,652	8.47	4,584,652	6/30/20
Invesco Advisers, Inc.	4,453,694	8.23	1,621	6/30/20
Consonance Capital Management LP	4,041,535	7.47	4,041,535	6/30/20
BlackRock Institutional Trust Company, N.A.	3,684,415	6.81	-115,426	6/30/20
The Vanguard Group, Inc.	3,281,884	6.06	32,556	6/30/20
Point72 Asset Management, L.P.	2,679,903	4.95	1,319,773	8/20/20
Wasatch Global Investors Inc	2,311,582	4.27	-301,453	6/30/20
Johnson & Johnson	1,923,077	3.55	--	12/31/18
State Street Global Advisors (US)	1,569,280	2.90	-346,568	6/30/20
Great Point Partners, LLC	1,500,000	2.77	1,500,000	6/30/20
Dimensional Fund Advisors, L.P.	1,367,326	2.53	8,731	6/30/20
Perceptive Advisors LLC	1,288,014	2.38	1,288,014	6/30/20
RTW Investments L.P.	1,245,816	2.30	1,245,816	6/30/20
Millennium Management LLC	1,182,821	2.19	-446,198	6/30/20
Koenig (Scott)	1,164,150	2.15	79,895	3/20/20
D. E. Shaw & Co., L.P.	854,652	1.58	444,300	6/30/20
Nuveen LLC	764,795	1.41	-126,760	6/30/20
Hood River Capital Management LLC	748,918	1.38	-739,624	6/30/20
Geode Capital Management, L.L.C.	745,606	1.38	2,088	6/30/20
Rhenman & Partners Asset Management AB	675,000	1.25	-325,000	6/30/20
Northern Trust Investments, Inc.	570,628	1.05	15,082	6/30/20
Pinnacle Associates Ltd.	523,306	0.97	-239,064	6/30/20
Opaleye Management Inc.	501,000	0.93	78,700	6/30/20
Adage Capital Management, L.P.	500,000	0.92	500,000	6/30/20
Fidelity Management & Research Company LLC	483,352	0.89	-98,691	6/30/20
Candriam Belgium S.A.	468,433	0.87	-279,330	6/30/20
Macquarie Investment Management	420,000	0.78	145,000	6/30/20
Arrowstreet Capital, Limited Partnership	398,338	0.74	347,538	6/30/20
Two Sigma Investments, LP	375,302	0.69	84,163	6/30/20
Charles Schwab Investment Management, Inc.	322,865	0.60	17,281	6/30/20
Citadel Advisors LLC	322,479	0.60	11,084	6/30/20
BlackRock Financial Management, Inc.	268,869	0.50	-7,555	6/30/20
Jacobs Levy Equity Management, Inc.	244,950	0.45	-13,446	6/30/20
BlackRock Advisors (UK) Limited	239,116	0.44	10,077	8/31/20
Goldman Sachs & Company, Inc.	235,391	0.44	113,071	6/30/20
Rock Springs Capital Management LP	234,516	0.43	4,516	6/30/20
Granahan Investment Management, Inc.	219,106	0.40	-5,532	6/30/20
BlackRock Asset Management Ireland Limited	218,563	0.40	-152,225	6/30/20
Atika Capital Management LLC	202,000	0.37	202,000	6/30/20
BlackRock Investment Management, LLC	199,280	0.37	9,619	6/30/20
PanAgora Asset Management Inc.	187,130	0.35	81,150	6/30/20
Principal Global Investors (Equity)	182,606	0.34	-37,488	6/30/20
Assenagon Asset Management S.A.	176,072	0.33	141,239	6/30/20
Wellington Management Company, LLP	175,616	0.32	-32,424	6/30/20
Acadian Asset Management LLC	169,756	0.31	9,491	6/30/20
Karrels (James)	152,460	0.28	4,473	3/20/20
MFS Investment Management	150,170	0.28	-3,826	6/30/20
Goldman Sachs Asset Management (US)	142,220	0.26	126,067	6/30/20
BNY Mellon Asset Management	128,067	0.24	6,064	6/30/20

* Insider values reflect direct beneficial ownership.