Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	231	1,236.18	96.51	59,117,304
Mutual Fund	267	444.79	34.78	21,265,578
Insider	7	49.11	2.60	1,595,102

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	91	126.85	9.89	6,057,222
Sellers	141	-225.39	15.64	-9,578,761
Net		-98.54	5.75	-3,521,539

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	1,285.29	99.11	60,712,406
Top 10 Inst.	821.04	64.01	39,209,156
Top 20 Inst.	1,015.68	78.19	47,897,848
Top 50 Inst.	1,198.21	92.48	56,650,263

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	52	279.49	21.79	13,347,719
Aggressive Growth	2	1.73	0.13	82,433
Core Growth	40	81.62	6.36	3,898,460
Growth	10	196.14	15.29	9,366,826
Income	3	3.37	0.26	160,876
Income Value	1	2.98	0.23	142,419
Yield	2	0.39	0.03	18,457
Index	30	302.51	23.68	14,504,133
Other	75	574.15	44.76	27,417,793
Broker Dealer	20	15.59	1.22	744,701
GARP	22	154.79	12.07	7,392,755
Hedge Fund	32	358.78	27.97	17,132,277
Specialty	--			--
VC Private Equity	1	44.98	3.51	2,148,060
Value	36	59.07	4.65	2,845,749
Core Value	29	28.17	2.23	1,368,152
Deep Value	7	30.89	2.41	1,477,597

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Bellevue Asset Management AG	8,544,597	13.95	1,168,571	9/30/21
RA Capital Management, LP	5,943,594	9.70	--	9/30/21
Wasatch Global Investors Inc	4,319,051	7.05	201,534	9/30/21
BlackRock Institutional Trust Company, N.A.	4,257,194	6.95	-139,578	9/30/21
RTW Investments L.P.	3,975,554	6.49	1,428,629	9/30/21
The Vanguard Group, Inc.	3,896,140	6.36	-44,924	9/30/21
State Street Global Advisors (US)	2,942,781	4.80	-288,778	9/30/21
Perceptive Advisors LLC	2,148,060	3.51	--	9/30/21
Victory Capital Management Inc.	1,965,101	3.21	315,629	9/30/21
Dimensional Fund Advisors, L.P.	1,217,084	1.99	-61,220	9/30/21
Koenig (Scott)	1,164,150	1.90	--	3/19/21
Geode Capital Management, L.L.C.	1,042,005	1.70	-4,746	9/30/21
Great Point Partners, LLC	1,000,000	1.63	-378,495	9/30/21
Fidelity Management & Research Company LLC	906,225	1.48	-229,625	9/30/21
Point72 Asset Management, L.P.	883,461	1.44	470,361	9/30/21
Citadel Advisors LLC	874,033	1.43	86,255	9/30/21
Woodline Partners LP	825,669	1.35	580,073	9/30/21
Fidelity Institutional Asset Management	742,810	1.21	-25,211	9/30/21
Rock Springs Capital Management LP	641,816	1.05	186,000	9/30/21
Candriam Belgium S.A.	608,523	0.99	--	9/30/21
Northern Trust Investments, Inc.	553,072	0.90	-12,631	9/30/21
Rhenman & Partners Asset Management AB	545,160	0.89	--	9/30/21
Millennium Management LLC	512,049	0.84	29,720	9/30/21
Wellington Management Company, LLP	469,162	0.77	-1,970	10/31/21
Opaleye Management Inc.	462,000	0.75	-116,150	9/30/21
Charles Schwab Investment Management, Inc.	450,030	0.73	-454	9/30/21
Baker Bros. Advisors LP	442,579	0.72	241,900	9/30/21
Macquarie Investment Management	420,000	0.69	--	9/30/21
BlackRock Financial Management, Inc.	418,505	0.68	-63,028	9/30/21
Pinnacle Associates Ltd.	416,558	0.68	-5,735	9/30/21
BlackRock Asset Management Ireland Limited	381,075	0.62	19,655	9/30/21
BlackRock Advisors (UK) Limited	374,547	0.61	-6,491	11/30/21
Ally Bridge Group NY LLC	365,000	0.60	252,161	9/30/21
Nuveen LLC	351,760	0.57	-7,315	9/30/21
Lord, Abbett & Co. LLC	281,307	0.46	-3,674	9/30/21
Principal Global Investors (Equity)	256,838	0.42	7,582	9/30/21
Goldman Sachs & Company, Inc.	246,896	0.40	58,366	9/30/21
Granahan Investment Management, Inc.	231,058	0.38	-28,384	9/30/21
Ikarian Capital LLC	188,478	0.31	-271,124	9/30/21
BlackRock Investment Management, LLC	170,982	0.28	-18,809	9/30/21
Integral Health Asset Management, LLC	160,000	0.26	160,000	9/30/21
Karrels (James)	143,460	0.23	-15,000	3/22/21
BNY Mellon Asset Management	142,419	0.23	7,672	9/30/21
Citi Investment Research (US)	141,122	0.23	-49,457	9/30/21
Bonvini Ezio	118,640	0.19	2,540	11/16/21
Schweizerische Nationalbank	106,100	0.17	6,900	9/30/21
PanAgora Asset Management Inc.	106,047	0.17	-125,003	9/30/21
Rafferty Asset Management LLC	103,931	0.17	-18,360	9/30/21
BlackRock Investment Management (UK) Ltd.	100,332	0.16	-1,274	9/30/21
HRT Financial LP	93,308	0.15	93,308	9/30/21

* Insider values reflect direct beneficial ownership.