| Bellevue Asset Management AG |
9,929,963 |
15.82 |
-12,350 |
9/30/24 |
| Armistice Capital LLC |
6,258,000 |
9.97 |
258,000 |
9/30/24 |
| BlackRock Institutional Trust Company, N.A. |
4,708,082 |
7.50 |
62,326 |
9/30/24 |
| The Vanguard Group, Inc. |
4,357,540 |
6.94 |
232,499 |
9/30/24 |
| Millennium Management LLC |
3,535,900 |
5.63 |
223,228 |
9/30/24 |
| Frazier Life Sciences Management, L.P. |
3,175,665 |
5.06 |
164,938 |
11/14/24 |
| Wasatch Global Investors Inc |
2,535,802 |
4.04 |
84,005 |
9/30/24 |
| Two Sigma Investments, LP |
1,927,373 |
3.07 |
-448,020 |
9/30/24 |
| State Street Global Advisors (US) |
1,427,390 |
2.27 |
-115,200 |
9/30/24 |
| Geode Capital Management, L.L.C. |
1,406,876 |
2.24 |
-8,363 |
9/30/24 |
| T. Rowe Price Associates, Inc. |
1,209,654 |
1.93 |
-86,150 |
9/30/24 |
| Acadian Asset Management LLC |
1,091,825 |
1.74 |
505,746 |
9/30/24 |
| Rock Springs Capital Management LP |
1,053,647 |
1.68 |
-- |
9/30/24 |
| Dimensional Fund Advisors, L.P. |
882,660 |
1.41 |
-15,837 |
9/30/24 |
| Koenig (Scott) |
871,195 |
1.39 |
-53,265 |
10/7/24 |
| Vestal Point Capital, LP |
830,000 |
1.32 |
30,000 |
9/30/24 |
| Connor, Clark & Lunn Investment Management Ltd. |
661,914 |
1.05 |
186,858 |
9/30/24 |
| Pinnacle Associates Ltd. |
637,319 |
1.02 |
-9,916 |
6/30/24 |
| Jacobs Levy Equity Management, Inc. |
566,328 |
0.90 |
147,438 |
9/30/24 |
| Jane Street Capital, L.L.C. |
522,197 |
0.83 |
34,996 |
9/30/24 |
| Northern Trust Investments, Inc. |
496,920 |
0.79 |
9,420 |
9/30/24 |
| Charles Schwab Investment Management, Inc. |
492,765 |
0.79 |
-17,740 |
9/30/24 |
| AQR Capital Management, LLC |
423,616 |
0.67 |
280,455 |
9/30/24 |
| Macquarie Investment Management |
420,000 |
0.67 |
-- |
9/30/24 |
| Marshall Wace LLP |
381,516 |
0.61 |
-276,491 |
9/30/24 |
| BlackRock Financial Management, Inc. |
362,789 |
0.58 |
-28,624 |
9/30/24 |
| PanAgora Asset Management Inc. |
354,835 |
0.57 |
-386,655 |
9/30/24 |
| Renaissance Technologies LLC |
318,423 |
0.51 |
-165,604 |
9/30/24 |
| Wellington Management Company, LLP |
307,140 |
0.49 |
41,733 |
9/30/24 |
| J.P. Morgan Securities LLC |
225,558 |
0.36 |
-115,605 |
9/30/24 |
| Morgan Stanley & Co. LLC |
220,783 |
0.35 |
-152,898 |
9/30/24 |
| Tang Capital Management, LLC |
218,856 |
0.35 |
-- |
9/30/24 |
| GSA Capital Partners LLP |
207,877 |
0.33 |
112,188 |
9/30/24 |
| Northern Trust Global Investments |
205,900 |
0.33 |
-17,240 |
9/30/24 |
| Nuveen LLC |
195,772 |
0.31 |
-- |
9/30/24 |
| Woodline Partners LP |
188,711 |
0.30 |
-180,831 |
9/30/24 |
| Karrels (James) |
171,452 |
0.27 |
-30,000 |
3/22/24 |
| TD Asset Management Inc. |
169,000 |
0.27 |
-- |
9/30/24 |
| Goldman Sachs & Company, Inc. |
160,469 |
0.26 |
-245,177 |
9/30/24 |
| PDT Partners, LLC |
160,039 |
0.26 |
49,288 |
9/30/24 |
| BlackRock Investment Management, LLC |
155,722 |
0.25 |
-6,280 |
9/30/24 |
| BofA Global Research (US) |
142,146 |
0.23 |
22,387 |
9/30/24 |
| Fidelity Management & Research Company LLC |
137,215 |
0.22 |
127,088 |
9/30/24 |
| Susquehanna Fundamental Investments, LLC |
129,996 |
0.21 |
24,209 |
6/30/24 |
| Manulife Investment Management (North America) Limited |
121,278 |
0.19 |
-754 |
9/30/24 |
| D. E. Shaw & Co., L.P. |
119,029 |
0.19 |
4,969 |
9/30/24 |
| BlackRock Asset Management Ireland Limited |
118,846 |
0.19 |
-4,349 |
9/30/24 |
| Walleye Capital LLC |
114,744 |
0.18 |
-89,201 |
9/30/24 |
| BlackRock Advisors (UK) Limited |
112,754 |
0.18 |
-5,139 |
11/30/24 |
| BNY Mellon Asset Management |
110,799 |
0.18 |
-31,774 |
9/30/24 |
