Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 181 607.34 98.76 48,311,444
Mutual Fund 413 285.50 52.41 25,629,411
Insider 10 27.86 3.19 1,558,926

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 95 52.12 8.43 4,127,573
Sellers 108 -87.84 12.65 -6,193,049
Net -35.72 4.22 -2,065,476

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 659.67 105.88 51,797,262
Top 10 Inst. 364.88 58.48 28,604,305
Top 20 Inst. 491.78 79.16 38,725,560
Top 50 Inst. 611.68 98.34 48,108,564

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 45 137.32 22.02 10,769,781
Aggressive Growth 2 1.06 0.17 83,090
Core Growth 32 61.84 9.92 4,853,924
Growth 11 74.42 11.92 5,832,767
Income 5 2.77 0.45 217,840
Income Value 1 1.44 0.23 113,063
Yield 4 1.32 0.21 104,777
Index 23 146.11 23.53 11,512,841
Other 63 281.57 46.42 22,711,818
Broker Dealer 14 4.09 0.66 320,419
GARP 22 149.22 24.58 12,024,806
Hedge Fund 24 108.64 17.72 8,670,211
Specialty 1 0.52 0.08 40,512
VC Private Equity 2 19.11 3.38 1,655,870
Value 18 32.10 5.14 2,514,491
Core Value 16 29.59 4.74 2,317,695
Deep Value 2 2.51 0.40 196,796

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 5,125,564 10.48 730,300 9/30/19
Invesco Advisers, Inc. 4,471,000 9.14 2,910 9/30/19
BlackRock Institutional Trust Company, N.A. 3,710,544 7.59 142,707 9/30/19
The Vanguard Group, Inc. 3,212,847 6.57 14,633 9/30/19
Millennium Management LLC 3,143,917 6.43 197,867 9/30/19
Columbia Wanger Asset Management, LLC 2,301,589 4.71 42,600 9/30/19
Johnson & Johnson 1,923,077 3.93 -- 12/31/18
State Street Global Advisors (US) 1,886,618 3.86 -737,257 9/30/19
Hood River Capital Management LLC 1,424,279 2.91 8,834 9/30/19
Wasatch Global Investors Inc 1,404,870 2.87 -17,375 9/30/19
GMT Capital Corp. 1,341,500 2.74 292,400 9/30/19
Dimensional Fund Advisors, L.P. 1,294,160 2.65 31,617 9/30/19
Fidelity Management & Research Company 1,097,543 2.24 -185,000 9/30/19
Koenig (Scott) 1,084,255 2.22 -- 3/22/19
InterWest Partners 1,074,316 2.19 -- 12/31/19
Rhenman & Partners Asset Management AB 1,060,000 2.17 260,627 12/31/19
Federated Global Investment Management Corp. 962,842 1.97 113,035 9/30/19
Candriam Belgium S.A. 754,988 1.54 -- 11/30/19
Candriam Luxembourg S.A. 747,763 1.53 -7,225 12/31/19
Nuveen LLC 703,888 1.44 -95,235 9/30/19
UBS Asset Management (Switzerland) 698,966 1.43 -- 9/30/19
Geode Capital Management, L.L.C. 613,193 1.25 15,064 9/30/19
Northern Trust Investments, Inc. 584,312 1.19 79,558 9/30/19
Sofinnova Investments, Inc 581,554 1.19 31,111 9/30/19
Pinnacle Associates Ltd. 552,080 1.13 -24,385 9/30/19
Renaissance Technologies LLC 434,353 0.89 9,930 9/30/19
683 Capital Management LLC 400,000 0.82 -134,970 9/30/19
Citadel LLC 398,333 0.81 377,984 9/30/19
Point72 Asset Management, L.P. 364,889 0.75 -80,683 9/30/19
BlackRock Advisors (UK) Limited 338,481 0.69 19,595 12/31/19
Victory Capital Management Inc. 326,779 0.67 220,179 9/30/19
BlackRock Asset Management Ireland Limited 309,843 0.63 -9,110 9/30/19
Rock Springs Capital Management LP 300,000 0.61 -- 9/30/19
Charles Schwab Investment Management, Inc. 294,039 0.60 31,120 9/30/19
Macquarie Investment Management 275,000 0.56 -- 9/30/19
BlackRock Financial Management, Inc. 272,314 0.56 31,668 9/30/19
D. E. Shaw & Co., L.P. 249,792 0.51 -48,646 9/30/19
PanAgora Asset Management Inc. 243,802 0.50 -56,785 9/30/19
Granahan Investment Management, Inc. 224,256 0.46 9,841 9/30/19
Principal Global Investors (Equity) 219,143 0.45 -15,689 9/30/19
Wellington Management Company, LLP 213,500 0.44 213,500 9/30/19
Dafna Capital Management, LLC 200,000 0.41 150,000 9/30/19
BlackRock Investment Management, LLC 181,265 0.37 6,618 9/30/19
361 Capital LLC 178,479 0.36 178,479 9/30/19
AXA Rosenberg Investment Management LLC 176,000 0.36 -2,400 9/30/19
Squarepoint Capital LLP 157,649 0.32 38,242 9/30/19
Eversept Partners, LP 154,824 0.32 -35,799 9/30/19
Bonvini Ezio 154,208 0.32 -- 3/22/19
MFS Investment Management 143,632 0.29 68,059 9/30/19
Numeric Investors LLC 142,318 0.29 -191,142 9/30/19

* Insider values reflect direct beneficial ownership.

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