Bellevue Asset Management AG |
5,282,188 |
9.40 |
280,072 |
9/30/20 |
Invesco Advisers, Inc. |
4,451,810 |
7.92 |
-1,884 |
9/30/20 |
RA Capital Management, LP |
4,375,217 |
7.78 |
-209,435 |
9/30/20 |
BlackRock Institutional Trust Company, N.A. |
3,839,080 |
6.83 |
154,665 |
9/30/20 |
Consonance Capital Management LP |
3,747,298 |
6.67 |
-294,237 |
9/30/20 |
Point72 Asset Management, L.P. |
3,595,079 |
6.40 |
915,176 |
9/30/20 |
The Vanguard Group, Inc. |
3,300,787 |
5.87 |
18,903 |
9/30/20 |
Wasatch Global Investors Inc |
2,433,724 |
4.33 |
122,142 |
9/30/20 |
State Street Global Advisors (US) |
2,309,668 |
4.11 |
740,388 |
9/30/20 |
Great Point Partners, LLC |
1,510,215 |
2.69 |
10,215 |
9/30/20 |
Dimensional Fund Advisors, L.P. |
1,360,785 |
2.42 |
-6,541 |
9/30/20 |
Perceptive Advisors LLC |
1,291,181 |
2.30 |
3,167 |
9/30/20 |
RTW Investments L.P. |
1,255,299 |
2.23 |
9,483 |
9/30/20 |
Fidelity Management & Research Company LLC |
1,169,553 |
2.08 |
686,201 |
9/30/20 |
Koenig (Scott) |
1,164,150 |
2.07 |
79,895 |
3/20/20 |
Nuveen LLC |
891,967 |
1.59 |
127,172 |
9/30/20 |
Geode Capital Management, L.L.C. |
785,369 |
1.40 |
39,763 |
9/30/20 |
D. E. Shaw & Co., L.P. |
729,464 |
1.30 |
-125,188 |
9/30/20 |
Hood River Capital Management LLC |
678,178 |
1.21 |
-70,740 |
9/30/20 |
Millennium Management LLC |
671,326 |
1.19 |
-511,495 |
9/30/20 |
Rhenman & Partners Asset Management AB |
635,711 |
1.13 |
-39,289 |
9/30/20 |
Northern Trust Investments, Inc. |
587,109 |
1.04 |
16,481 |
9/30/20 |
Candriam Belgium S.A. |
581,854 |
1.04 |
113,421 |
9/30/20 |
Citadel Advisors LLC |
572,575 |
1.02 |
250,096 |
9/30/20 |
Opaleye Management Inc. |
527,000 |
0.94 |
26,000 |
9/30/20 |
Pinnacle Associates Ltd. |
427,396 |
0.76 |
-95,910 |
9/30/20 |
Macquarie Investment Management |
420,000 |
0.75 |
-- |
9/30/20 |
BlackRock Financial Management, Inc. |
379,577 |
0.68 |
110,708 |
9/30/20 |
Two Sigma Investments, LP |
368,926 |
0.66 |
-6,376 |
9/30/20 |
Charles Schwab Investment Management, Inc. |
350,075 |
0.62 |
27,210 |
9/30/20 |
BlackRock Advisors (UK) Limited |
278,213 |
0.50 |
16,417 |
12/31/20 |
Rock Springs Capital Management LP |
262,641 |
0.47 |
28,125 |
9/30/20 |
BlackRock Asset Management Ireland Limited |
256,327 |
0.46 |
37,764 |
9/30/20 |
BlackRock Investment Management, LLC |
204,729 |
0.36 |
5,449 |
9/30/20 |
PanAgora Asset Management Inc. |
204,618 |
0.36 |
17,488 |
9/30/20 |
Atika Capital Management LLC |
203,000 |
0.36 |
1,000 |
9/30/20 |
Principal Global Investors (Equity) |
189,487 |
0.34 |
6,881 |
9/30/20 |
Granahan Investment Management, Inc. |
183,875 |
0.33 |
-35,231 |
9/30/20 |
Arrowstreet Capital, Limited Partnership |
180,658 |
0.32 |
-217,680 |
9/30/20 |
Wellington Management Company, LLP |
170,541 |
0.30 |
-5,075 |
9/30/20 |
Goldman Sachs & Company, Inc. |
162,307 |
0.29 |
-73,084 |
9/30/20 |
Karrels (James) |
152,460 |
0.27 |
4,473 |
3/20/20 |
BofA Global Research (US) |
144,112 |
0.26 |
20,046 |
9/30/20 |
BNY Mellon Asset Management |
130,575 |
0.23 |
2,508 |
9/30/20 |
Goldman Sachs Asset Management (US) |
121,410 |
0.22 |
-20,810 |
9/30/20 |
California Public Employees' Retirement System |
119,488 |
0.21 |
22,488 |
9/30/20 |
MFS Investment Management |
113,950 |
0.20 |
-36,220 |
9/30/20 |
Schweizerische Nationalbank |
105,800 |
0.19 |
1,900 |
9/30/20 |
Endurant Capital Management LP |
97,374 |
0.17 |
97,374 |
9/30/20 |
Bonvini Ezio |
91,357 |
0.16 |
-62,851 |
9/18/20 |