Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 231 962.13 104.43 65,407,573
Mutual Fund 212 252.74 36.39 22,610,505
Insider 9 24.65 2.63 1,649,621

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 131 254.63 27.65 17,296,004
Sellers 98 -224.54 25.04 -15,668,038
Net 30.09 2.60 1,627,966

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 986.78 107.06 67,057,194
Top 10 Inst. 604.86 65.61 41,091,293
Top 20 Inst. 746.99 81.02 50,746,412
Top 50 Inst. 904.25 98.08 61,430,020

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 51 197.86 21.47 13,449,908
Aggressive Growth 4 3.87 0.42 262,982
Core Growth 37 39.04 4.25 2,660,588
Growth 10 154.95 16.81 10,526,338
Income 5 5.45 0.59 370,127
Income Value 2 4.99 0.54 339,193
Yield 3 0.46 0.05 30,934
Index 32 242.17 26.31 16,479,895
Other 82 453.33 49.18 30,804,759
Broker Dealer 16 34.10 3.70 2,316,474
GARP 29 137.44 14.91 9,338,189
Hedge Fund 33 185.08 20.09 12,580,384
Specialty 1 0.19 0.02 12,640
VC Private Equity 3 96.52 10.47 6,557,072
Value 31 42.88 4.66 2,916,299
Core Value 23 16.04 1.75 1,093,182
Deep Value 8 26.84 2.91 1,823,117

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 9,965,862 15.91 12,549 3/31/24
Avoro Capital Advisors LLC 6,150,000 9.82 6,150,000 3/31/24
BlackRock Institutional Trust Company, N.A. 4,790,878 7.65 -147,824 3/31/24
State Street Global Advisors (US) 4,389,647 7.01 2,215,625 3/31/24
The Vanguard Group, Inc. 3,667,400 5.86 -641,994 3/31/24
T. Rowe Price Investment Management, Inc. 2,767,034 4.42 -2,872,960 3/31/24
Frazier Life Sciences Management, L.P. 2,471,704 3.95 70,000 3/31/24
T. Rowe Price Associates, Inc. 2,406,747 3.84 2,331,670 3/31/24
Armistice Capital LLC 2,400,000 3.83 -2,172,000 3/31/24
RA Capital Management, LP 2,082,021 3.32 -1,971,056 3/31/24
Geode Capital Management, L.L.C. 1,432,013 2.29 27,945 3/31/24
Rock Springs Capital Management LP 1,305,250 2.08 126,454 3/31/24
Koenig (Scott) 1,298,675 2.07 -- 3/22/24
Dimensional Fund Advisors, L.P. 1,051,259 1.68 -163,641 3/31/24
Wasatch Global Investors Inc 989,579 1.58 -307,995 3/31/24
JP Morgan Asset Management 944,616 1.51 -70,464 3/31/24
Vestal Point Capital, LP 725,000 1.16 725,000 3/31/24
Renaissance Technologies LLC 715,027 1.14 -48,500 3/31/24
Pinnacle Associates Ltd. 647,235 1.03 -40,745 3/31/24
Nuveen LLC 546,465 0.87 -57,465 3/31/24
Susquehanna International Group, LLP 531,922 0.85 451,700 3/31/24
Charles Schwab Investment Management, Inc. 522,946 0.83 -310,554 3/31/24
BlackRock Financial Management, Inc. 508,648 0.81 -335,764 3/31/24
Northern Trust Investments, Inc. 505,429 0.81 8,242 3/31/24
Integral Health Asset Management, LLC 500,000 0.80 50,000 3/31/24
SilverArc Capital Management, LLC 478,079 0.76 -780,562 3/31/24
Acadian Asset Management LLC 473,413 0.76 -584,280 3/31/24
PanAgora Asset Management Inc. 463,430 0.74 64,486 3/31/24
Federated MDTA LLC 453,732 0.72 -349,643 3/31/24
Macquarie Investment Management 420,000 0.67 -- 3/31/24
Connor, Clark & Lunn Investment Management Ltd. 418,282 0.67 174,086 3/31/24
Jane Street Capital, L.L.C. 378,523 0.60 305,684 3/31/24
Perceptive Advisors LLC 378,327 0.60 -233,605 3/31/24
Woodline Partners LP 365,425 0.58 365,425 3/31/24
Citadel Advisors LLC 364,234 0.58 181,750 3/31/24
Rafferty Asset Management LLC 352,695 0.56 257,963 3/31/24
Principal Global Investors (Equity) 344,603 0.55 76,727 3/31/24
Ikarian Capital LLC 318,167 0.51 318,167 3/31/24
BofA Global Research (US) 310,900 0.50 168,482 3/31/24
Citi Investment Research (US) 305,076 0.49 258,605 3/31/24
Commodore Capital LP 295,020 0.47 295,020 3/31/24
UBS Financial Services, Inc. 258,359 0.41 125,348 3/31/24
Qube Research & Technologies Ltd 246,483 0.39 215,937 3/31/24
Wellington Management Company, LLP 245,831 0.39 7,708 3/31/24
Northern Trust Global Investments 225,457 0.36 -51,835 3/31/24
Goldman Sachs & Company, Inc. 219,895 0.35 94,161 3/31/24
TD Asset Management Inc. 213,448 0.34 138,400 3/31/24
Banque Pictet & Cie S.A. 208,698 0.33 208,698 3/31/24
Franklin Advisers, Inc. 205,134 0.33 148,307 3/31/24
Karrels (James) 171,452 0.27 -30,000 3/22/24

* Insider values reflect direct beneficial ownership.

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