Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	185	511.54	96.17	47,083,387
Mutual Fund	416	267.85	56.20	27,509,848
Insider	10	13.25	3.50	1,715,062

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	97	56.77	10.80	5,291,106
Sellers	87	-88.25	15.98	-7,827,006
Net		-31.49	5.18	-2,535,900

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	549.22	103.62	50,727,133
Top 10 Inst.	314.46	58.38	28,581,248
Top 20 Inst.	413.43	78.20	38,280,959
Top 50 Inst.	508.76	96.18	47,088,021

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	42	128.90	24.21	11,851,419
Aggressive Growth	2	0.59	0.11	54,732
Core Growth	31	57.89	10.88	5,324,641
Growth	9	70.42	13.22	6,472,046
Income	3	2.50	0.47	230,856
Income Value	1	1.35	0.25	124,417
Yield	2	1.14	0.22	106,439
Index	24	127.37	24.07	11,786,110
Other	63	228.95	42.96	21,033,703
Broker Dealer	12	3.55	0.67	326,515
GARP	23	128.75	24.17	11,833,721
Hedge Fund	26	72.19	13.53	6,625,269
Specialty	--	--	--	--
VC Private Equity	2	24.46	4.59	2,248,198
Value	26	18.40	3.44	1,686,400
Core Value	21	16.10	3.01	1,473,922
Deep Value	5	2.31	0.43	212,478

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Bellevue Asset Management AG	5,873,356	12.00	747,792	12/31/19
Invesco Advisers, Inc.	4,482,536	9.16	11,536	12/31/19
BlackRock Institutional Trust Company, N.A.	3,792,725	7.75	82,181	12/31/19
The Vanguard Group, Inc.	3,209,530	6.56	-3,317	12/31/19
Millennium Management LLC	2,314,831	4.73	-829,086	12/31/19
Wasatch Global Investors Inc	2,197,701	4.49	792,831	12/31/19
State Street Global Advisors (US)	1,930,610	3.94	43,992	12/31/19
Johnson & Johnson	1,923,077	3.93	--	12/31/18
Hood River Capital Management LLC	1,505,352	3.07	81,073	12/31/19
Columbia Wanger Asset Management, LLC	1,351,530	2.76	-950,059	12/31/19
Dimensional Fund Advisors, L.P.	1,304,737	2.67	10,577	12/31/19
Koenig (Scott)	1,217,418	2.49	133,163	3/11/20
Sofinnova Investments, Inc	1,173,882	2.40	592,328	12/31/19
InterWest Partners	1,074,316	2.19	--	12/31/19
Rhenman & Partners Asset Management AB	1,060,000	2.17	260,627	12/31/19
Pinnacle Associates Ltd.	858,945	1.75	306,865	12/31/19
Fidelity Management & Research Company	830,443	1.70	-267,100	12/31/19
Candriam Luxembourg S.A.	747,763	1.53	-7,225	12/31/19
Candriam Belgium S.A.	721,179	1.47	-33,809	12/31/19
UBS Asset Management (Switzerland)	711,028	1.45	12,062	12/31/19
Nuveen LLC	706,895	1.44	3,007	12/31/19
Geode Capital Management, L.L.C.	691,002	1.41	77,809	12/31/19
D. E. Shaw & Co., L.P.	609,152	1.24	359,360	12/31/19
Northern Trust Investments, Inc.	559,888	1.14	-24,424	12/31/19
Renaissance Technologies LLC	452,123	0.92	17,770	12/31/19
BlackRock Advisors (UK) Limited	363,152	0.74	8,161	2/29/20
BlackRock Asset Management Ireland Limited	348,889	0.71	39,046	12/31/19
PanAgora Asset Management Inc.	343,656	0.70	99,854	12/31/19
GMT Capital Corp.	328,278	0.67	-1,013,222	12/31/19
Two Sigma Investments, LP	327,208	0.67	327,208	12/31/19
Victory Capital Management Inc.	323,658	0.66	-3,121	12/31/19
Charles Schwab Investment Management, Inc.	299,664	0.61	5,625	12/31/19
Macquarie Investment Management	275,000	0.56	--	12/31/19
Principal Global Investors (Equity)	269,926	0.55	50,783	12/31/19
BlackRock Financial Management, Inc.	261,799	0.53	-10,515	12/31/19
Citadel Advisors LLC	249,531	0.51	-148,802	12/31/19
Rock Springs Capital Management LP	230,000	0.47	-70,000	12/31/19
Granahan Investment Management, Inc.	225,951	0.46	1,695	12/31/19
Wellington Management Company, LLP	213,500	0.44	--	12/31/19
Opaleye Management Inc.	200,500	0.41	200,500	12/31/19
BlackRock Investment Management, LLC	181,192	0.37	-73	12/31/19
AXA Rosenberg Investment Management LLC	176,000	0.36	--	12/31/19
Bonvini Ezio	154,208	0.32	--	3/22/19
Numeric Investors LLC	153,318	0.31	11,000	12/31/19
Karrels (James)	152,460	0.31	4,473	3/6/20
Dafna Capital Management, LLC	150,000	0.31	-50,000	12/31/19
Bogle Investment Management, L.P.	149,539	0.31	90,922	12/31/19
OxFORD Asset Management	142,481	0.29	88,515	12/31/19
Deutsche Asset Management Americas	138,471	0.28	76,073	12/31/19
MFS Investment Management	129,621	0.26	-14,011	12/31/19

* Insider values reflect direct beneficial ownership.