Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 181 614.78 98.67 48,263,794
Mutual Fund 408 287.32 54.00 26,397,170
Insider 10 27.86 3.19 1,558,926

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 95 50.36 8.14 3,981,397
Sellers 108 -89.32 12.77 -6,248,262
Net -38.97 4.63 -2,266,865

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 663.90 105.80 51,749,449
Top 10 Inst. 364.88 58.48 28,604,305
Top 20 Inst. 493.23 78.65 38,472,158
Top 50 Inst. 612.22 97.88 47,877,289

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 46 139.59 22.21 10,863,867
Aggressive Growth 2 1.06 0.17 83,090
Core Growth 32 61.98 9.94 4,863,661
Growth 12 76.55 12.10 5,917,116
Income 5 2.76 0.45 217,840
Income Value 1 1.44 0.23 113,063
Yield 4 1.31 0.21 104,777
Index 24 145.49 23.49 11,489,490
Other 62 287.36 46.19 22,593,844
Broker Dealer 14 3.97 0.64 311,275
GARP 21 154.10 24.84 12,149,768
Hedge Fund 24 107.65 17.25 8,436,419
Specialty 1 0.52 0.08 40,512
VC Private Equity 2 21.13 3.39 1,655,870
Value 19 32.15 5.15 2,517,621
Core Value 17 29.64 4.74 2,320,825
Deep Value 2 2.51 0.40 196,796

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 5,125,564 10.48 730,300 9/30/19
Invesco Advisers, Inc. 4,471,000 9.14 2,910 9/30/19
BlackRock Institutional Trust Company, N.A. 3,710,544 7.59 142,707 9/30/19
The Vanguard Group, Inc. 3,212,847 6.57 14,633 9/30/19
Millennium Management LLC 3,143,917 6.43 197,867 9/30/19
Columbia Wanger Asset Management, LLC 2,301,589 4.71 42,600 9/30/19
Johnson & Johnson 1,923,077 3.93 -- 12/31/18
State Street Global Advisors (US) 1,886,618 3.86 -737,257 9/30/19
Hood River Capital Management LLC 1,424,279 2.91 8,834 9/30/19
Wasatch Global Investors Inc 1,404,870 2.87 -17,375 9/30/19
GMT Capital Corp. 1,341,500 2.74 292,400 9/30/19
Dimensional Fund Advisors, L.P. 1,294,160 2.65 31,617 9/30/19
Fidelity Management & Research Company 1,097,543 2.24 -185,000 9/30/19
Koenig (Scott) 1,084,255 2.22 -- 3/22/19
InterWest Partners 1,074,316 2.20 -- 9/30/19
Federated Global Investment Management Corp. 962,842 1.97 113,035 9/30/19
Rhenman & Partners Asset Management AB 799,373 1.63 -57,796 9/30/19
Candriam Luxembourg S.A. 754,988 1.54 4,000 9/30/19
Candriam Belgium S.A. 754,988 1.54 -- 10/31/19
Nuveen LLC 703,888 1.44 -95,235 9/30/19
UBS Asset Management (Switzerland) 698,966 1.43 -- 9/30/19
Geode Capital Management, L.L.C. 613,193 1.25 15,064 9/30/19
Northern Trust Investments, Inc. 584,312 1.19 79,558 9/30/19
Sofinnova Investments, Inc 581,554 1.19 31,111 9/30/19
Pinnacle Associates Ltd. 552,080 1.13 -24,385 9/30/19
Renaissance Technologies LLC 434,353 0.89 9,930 9/30/19
683 Capital Management LLC 400,000 0.82 -134,970 9/30/19
Citadel LLC 398,333 0.81 377,984 9/30/19
Point72 Asset Management, L.P. 364,889 0.75 -80,683 9/30/19
Victory Capital Management Inc. 326,779 0.67 220,179 9/30/19
BlackRock Advisors (UK) Limited 318,886 0.65 13,973 11/30/19
BlackRock Asset Management Ireland Limited 309,843 0.63 -9,110 9/30/19
Rock Springs Capital Management LP 300,000 0.61 -- 9/30/19
Charles Schwab Investment Management, Inc. 294,039 0.60 31,120 9/30/19
Macquarie Investment Management 275,000 0.56 -- 9/30/19
BlackRock Financial Management, Inc. 272,314 0.56 31,668 9/30/19
D. E. Shaw & Co., L.P. 249,792 0.51 -48,646 9/30/19
PanAgora Asset Management Inc. 243,802 0.50 -56,785 9/30/19
Granahan Investment Management, Inc. 224,256 0.46 9,841 9/30/19
Principal Global Investors (Equity) 219,143 0.45 -15,689 9/30/19
Wellington Management Company, LLP 216,000 0.44 216,000 9/30/19
Dafna Capital Management, LLC 200,000 0.41 150,000 9/30/19
Medical Strategy GmbH 181,540 0.37 65,000 10/31/19
BlackRock Investment Management, LLC 181,265 0.37 6,618 9/30/19
361 Capital LLC 178,479 0.36 178,479 9/30/19
AXA Rosenberg Investment Management LLC 176,000 0.36 -2,400 9/30/19
Squarepoint Capital LLP 157,649 0.32 38,242 9/30/19
Eversept Partners, LP 154,824 0.32 -35,799 9/30/19
Bonvini Ezio 154,208 0.32 -- 3/22/19
MFS Investment Management 143,632 0.29 68,059 9/30/19

* Insider values reflect direct beneficial ownership.

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