Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	181	614.78	98.67	48,263,794
Mutual Fund	408	287.32	54.00	26,397,170
Insider	10	27.86	3.19	1,558,926

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	95	50.36	8.14	3,981,397
Sellers	108	-89.32	12.77	-6,248,262
Net		-38.97	4.63	-2,266,865

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	663.90	105.80	51,749,449
Top 10 Inst.	364.88	58.48	28,604,305
Top 20 Inst.	493.23	78.65	38,472,158
Top 50 Inst.	612.22	97.88	47,877,289

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	46	139.59	22.21	10,863,867
Aggressive Growth	2	1.06	0.17	83,090
Core Growth	32	61.98	9.94	4,863,661
Growth	12	76.55	12.10	5,917,116
Income	5	2.76	0.45	217,840
Income Value	1	1.44	0.23	113,063
Yield	4	1.31	0.21	104,777
Index	24	145.49	23.49	11,489,490
Other	62	287.36	46.19	22,593,844
Broker Dealer	14	3.97	0.64	311,275
GARP	21	154.10	24.84	12,149,768
Hedge Fund	24	107.65	17.25	8,436,419
Specialty	1	0.52	0.08	40,512
VC Private Equity	2	21.13	3.39	1,655,870
Value	19	32.15	5.15	2,517,621
Core Value	17	29.64	4.74	2,320,825
Deep Value	2	2.51	0.40	196,796

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Bellevue Asset Management AG	5,125,564	10.48	730,300	9/30/19
Invesco Advisers, Inc.	4,471,000	9.14	2,910	9/30/19
BlackRock Institutional Trust Company, N.A.	3,710,544	7.59	142,707	9/30/19
The Vanguard Group, Inc.	3,212,847	6.57	14,633	9/30/19
Millennium Management LLC	3,143,917	6.43	197,867	9/30/19
Columbia Wanger Asset Management, LLC	2,301,589	4.71	42,600	9/30/19
Johnson & Johnson	1,923,077	3.93	--	12/31/18
State Street Global Advisors (US)	1,886,618	3.86	-737,257	9/30/19
Hood River Capital Management LLC	1,424,279	2.91	8,834	9/30/19
Wasatch Global Investors Inc	1,404,870	2.87	-17,375	9/30/19
GMT Capital Corp.	1,341,500	2.74	292,400	9/30/19
Dimensional Fund Advisors, L.P.	1,294,160	2.65	31,617	9/30/19
Fidelity Management & Research Company	1,097,543	2.24	-185,000	9/30/19
Koenig (Scott)	1,084,255	2.22	--	3/22/19
InterWest Partners	1,074,316	2.20	--	9/30/19
Federated Global Investment Management Corp.	962,842	1.97	113,035	9/30/19
Rhenman & Partners Asset Management AB	799,373	1.63	-57,796	9/30/19
Candriam Luxembourg S.A.	754,988	1.54	4,000	9/30/19
Candriam Belgium S.A.	754,988	1.54	--	10/31/19
Nuveen LLC	703,888	1.44	-95,235	9/30/19
UBS Asset Management (Switzerland)	698,966	1.43	--	9/30/19
Geode Capital Management, L.L.C.	613,193	1.25	15,064	9/30/19
Northern Trust Investments, Inc.	584,312	1.19	79,558	9/30/19
Sofinnova Investments, Inc	581,554	1.19	31,111	9/30/19
Pinnacle Associates Ltd.	552,080	1.13	-24,385	9/30/19
Renaissance Technologies LLC	434,353	0.89	9,930	9/30/19
683 Capital Management LLC	400,000	0.82	-134,970	9/30/19
Citadel LLC	398,333	0.81	377,984	9/30/19
Point72 Asset Management, L.P.	364,889	0.75	-80,683	9/30/19
Victory Capital Management Inc.	326,779	0.67	220,179	9/30/19
BlackRock Advisors (UK) Limited	318,886	0.65	13,973	11/30/19
BlackRock Asset Management Ireland Limited	309,843	0.63	-9,110	9/30/19
Rock Springs Capital Management LP	300,000	0.61	--	9/30/19
Charles Schwab Investment Management, Inc.	294,039	0.60	31,120	9/30/19
Macquarie Investment Management	275,000	0.56	--	9/30/19
BlackRock Financial Management, Inc.	272,314	0.56	31,668	9/30/19
D. E. Shaw & Co., L.P.	249,792	0.51	-48,646	9/30/19
PanAgora Asset Management Inc.	243,802	0.50	-56,785	9/30/19
Granahan Investment Management, Inc.	224,256	0.46	9,841	9/30/19
Principal Global Investors (Equity)	219,143	0.45	-15,689	9/30/19
Wellington Management Company, LLP	216,000	0.44	216,000	9/30/19
Dafna Capital Management, LLC	200,000	0.41	150,000	9/30/19
Medical Strategy GmbH	181,540	0.37	65,000	10/31/19
BlackRock Investment Management, LLC	181,265	0.37	6,618	9/30/19
361 Capital LLC	178,479	0.36	178,479	9/30/19
AXA Rosenberg Investment Management LLC	176,000	0.36	-2,400	9/30/19
Squarepoint Capital LLP	157,649	0.32	38,242	9/30/19
Eversept Partners, LP	154,824	0.32	-35,799	9/30/19
Bonvini Ezio	154,208	0.32	--	3/22/19
MFS Investment Management	143,632	0.29	68,059	9/30/19

* Insider values reflect direct beneficial ownership.