| Bellevue Asset Management AG |
9,965,862 |
15.91 |
12,549 |
3/31/24 |
| Avoro Capital Advisors LLC |
6,150,000 |
9.82 |
6,150,000 |
3/31/24 |
| BlackRock Institutional Trust Company, N.A. |
4,790,878 |
7.65 |
-147,824 |
3/31/24 |
| State Street Global Advisors (US) |
4,389,647 |
7.01 |
2,215,625 |
3/31/24 |
| The Vanguard Group, Inc. |
3,667,400 |
5.86 |
-641,994 |
3/31/24 |
| Millennium Management LLC |
3,209,974 |
5.13 |
505,258 |
6/3/24 |
| T. Rowe Price Investment Management, Inc. |
2,767,034 |
4.42 |
-2,872,960 |
3/31/24 |
| Frazier Life Sciences Management, L.P. |
2,471,704 |
3.95 |
70,000 |
3/31/24 |
| T. Rowe Price Associates, Inc. |
2,406,747 |
3.84 |
2,331,670 |
3/31/24 |
| Armistice Capital LLC |
2,400,000 |
3.83 |
-2,172,000 |
3/31/24 |
| RA Capital Management, LP |
2,082,021 |
3.32 |
-1,971,056 |
3/31/24 |
| Geode Capital Management, L.L.C. |
1,432,013 |
2.29 |
27,945 |
3/31/24 |
| Rock Springs Capital Management LP |
1,305,250 |
2.08 |
126,454 |
3/31/24 |
| Koenig (Scott) |
1,298,675 |
2.07 |
-- |
3/22/24 |
| Dimensional Fund Advisors, L.P. |
1,051,259 |
1.68 |
-163,641 |
3/31/24 |
| Wasatch Global Investors Inc |
989,579 |
1.58 |
-307,995 |
3/31/24 |
| JP Morgan Asset Management |
944,616 |
1.51 |
-70,464 |
3/31/24 |
| Vestal Point Capital, LP |
725,000 |
1.16 |
725,000 |
3/31/24 |
| Renaissance Technologies LLC |
715,027 |
1.14 |
-48,500 |
3/31/24 |
| Pinnacle Associates Ltd. |
647,235 |
1.03 |
-40,745 |
3/31/24 |
| Nuveen LLC |
546,465 |
0.87 |
-57,465 |
3/31/24 |
| Susquehanna International Group, LLP |
531,922 |
0.85 |
451,700 |
3/31/24 |
| Charles Schwab Investment Management, Inc. |
522,946 |
0.83 |
-310,554 |
3/31/24 |
| BlackRock Financial Management, Inc. |
508,648 |
0.81 |
-335,764 |
3/31/24 |
| Northern Trust Investments, Inc. |
505,429 |
0.81 |
8,242 |
3/31/24 |
| Integral Health Asset Management, LLC |
500,000 |
0.80 |
50,000 |
3/31/24 |
| SilverArc Capital Management, LLC |
478,079 |
0.76 |
-780,562 |
3/31/24 |
| Acadian Asset Management LLC |
473,413 |
0.76 |
-584,280 |
3/31/24 |
| PanAgora Asset Management Inc. |
463,430 |
0.74 |
64,486 |
3/31/24 |
| Federated MDTA LLC |
453,732 |
0.72 |
-349,643 |
3/31/24 |
| Macquarie Investment Management |
420,000 |
0.67 |
-- |
3/31/24 |
| Connor, Clark & Lunn Investment Management Ltd. |
418,282 |
0.67 |
174,086 |
3/31/24 |
| Jane Street Capital, L.L.C. |
378,523 |
0.60 |
305,684 |
3/31/24 |
| Perceptive Advisors LLC |
378,327 |
0.60 |
-233,605 |
3/31/24 |
| Woodline Partners LP |
365,425 |
0.58 |
365,425 |
3/31/24 |
| Citadel Advisors LLC |
364,234 |
0.58 |
181,750 |
3/31/24 |
| Rafferty Asset Management LLC |
352,695 |
0.56 |
257,963 |
3/31/24 |
| Principal Global Investors (Equity) |
344,603 |
0.55 |
76,727 |
3/31/24 |
| Ikarian Capital LLC |
318,167 |
0.51 |
318,167 |
3/31/24 |
| BofA Global Research (US) |
310,900 |
0.50 |
168,482 |
3/31/24 |
| Citi Investment Research (US) |
305,076 |
0.49 |
258,605 |
3/31/24 |
| Commodore Capital LP |
295,020 |
0.47 |
295,020 |
3/31/24 |
| UBS Financial Services, Inc. |
258,359 |
0.41 |
125,348 |
3/31/24 |
| Qube Research & Technologies Ltd |
246,483 |
0.39 |
215,937 |
3/31/24 |
| Wellington Management Company, LLP |
245,831 |
0.39 |
7,708 |
3/31/24 |
| Northern Trust Global Investments |
225,457 |
0.36 |
-51,835 |
3/31/24 |
| Goldman Sachs & Company, Inc. |
219,895 |
0.35 |
94,161 |
3/31/24 |
| TD Asset Management Inc. |
213,448 |
0.34 |
138,400 |
3/31/24 |
| Franklin Advisers, Inc. |
205,134 |
0.33 |
148,307 |
3/31/24 |
| Karrels (James) |
171,452 |
0.27 |
-30,000 |
3/22/24 |
