Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 208 1,492.06 98.72 53,426,263
Mutual Fund 284 430.49 32.76 17,369,127
Insider 10 13.30 2.96 1,603,749

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 110 482.94 32.03 17,332,228
Sellers 110 -310.85 23.30 -12,609,521
Net 172.09 8.73 4,722,707

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 1,529.82 105.25 56,956,904
Top 10 Inst. 909.68 61.96 33,532,138
Top 20 Inst. 1,187.22 82.03 44,394,236
Top 50 Inst. 1,437.80 98.82 53,480,827

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 54 284.74 18.88 10,216,779
Aggressive Growth 3 8.01 0.53 286,919
Core Growth 40 116.23 7.71 4,173,976
Growth 11 160.50 10.64 5,755,884
Income 4 3.65 0.25 135,426
Income Value 1 3.58 0.24 128,067
Yield 3 0.07 0.01 7,359
Index 26 317.72 21.01 11,371,269
Other 72 851.84 56.27 30,453,805
Broker Dealer 19 17.60 1.16 629,277
GARP 19 248.40 16.44 8,899,302
Hedge Fund 32 549.21 36.24 19,613,484
Specialty 1 0.66 0.04 23,728
VC Private Equity 1 35.96 2.38 1,288,014
Value 26 24.92 1.67 902,838
Core Value 22 14.43 0.97 526,700
Deep Value 4 10.49 0.70 376,138

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 5,002,116 9.24 -1,117,034 6/30/20
RA Capital Management, LP 4,584,652 8.47 4,584,652 6/30/20
Invesco Advisers, Inc. 4,453,694 8.23 1,621 6/30/20
Consonance Capital Management LP 4,041,535 7.47 4,041,535 6/30/20
BlackRock Institutional Trust Company, N.A. 3,684,415 6.81 -115,426 6/30/20
The Vanguard Group, Inc. 3,281,884 6.06 32,556 6/30/20
Point72 Asset Management, L.P. 2,679,903 4.95 1,319,773 8/20/20
Wasatch Global Investors Inc 2,311,582 4.27 -301,453 6/30/20
Johnson & Johnson 1,923,077 3.55 -- 12/31/18
State Street Global Advisors (US) 1,569,280 2.90 -346,568 6/30/20
Great Point Partners, LLC 1,500,000 2.77 1,500,000 6/30/20
Dimensional Fund Advisors, L.P. 1,367,326 2.53 8,731 6/30/20
Perceptive Advisors LLC 1,288,014 2.38 1,288,014 6/30/20
RTW Investments L.P. 1,245,816 2.30 1,245,816 6/30/20
Millennium Management LLC 1,182,821 2.19 -446,198 6/30/20
Koenig (Scott) 1,164,150 2.15 79,895 3/20/20
D. E. Shaw & Co., L.P. 854,652 1.58 444,300 6/30/20
Nuveen LLC 764,795 1.41 -126,760 6/30/20
Hood River Capital Management LLC 748,918 1.38 -739,624 6/30/20
Geode Capital Management, L.L.C. 745,606 1.38 2,088 6/30/20
Rhenman & Partners Asset Management AB 675,000 1.25 -325,000 6/30/20
Northern Trust Investments, Inc. 570,628 1.05 15,082 6/30/20
Pinnacle Associates Ltd. 523,306 0.97 -239,064 6/30/20
Opaleye Management Inc. 501,000 0.93 78,700 6/30/20
Adage Capital Management, L.P. 500,000 0.92 500,000 6/30/20
Fidelity Management & Research Company LLC 483,352 0.89 -98,691 6/30/20
Candriam Belgium S.A. 468,433 0.87 -279,330 6/30/20
Macquarie Investment Management 420,000 0.78 145,000 6/30/20
Arrowstreet Capital, Limited Partnership 398,338 0.74 347,538 6/30/20
Two Sigma Investments, LP 375,302 0.69 84,163 6/30/20
Charles Schwab Investment Management, Inc. 322,865 0.60 17,281 6/30/20
Citadel Advisors LLC 322,479 0.60 11,084 6/30/20
BlackRock Financial Management, Inc. 268,869 0.50 -7,555 6/30/20
Jacobs Levy Equity Management, Inc. 244,950 0.45 -13,446 6/30/20
BlackRock Advisors (UK) Limited 239,116 0.44 10,077 8/31/20
Goldman Sachs & Company, Inc. 235,391 0.44 113,071 6/30/20
Rock Springs Capital Management LP 234,516 0.43 4,516 6/30/20
Granahan Investment Management, Inc. 219,106 0.40 -5,532 6/30/20
BlackRock Asset Management Ireland Limited 218,563 0.40 -152,225 6/30/20
Atika Capital Management LLC 202,000 0.37 202,000 6/30/20
BlackRock Investment Management, LLC 199,280 0.37 9,619 6/30/20
PanAgora Asset Management Inc. 187,130 0.35 81,150 6/30/20
Principal Global Investors (Equity) 182,606 0.34 -37,488 6/30/20
Assenagon Asset Management S.A. 176,072 0.33 141,239 6/30/20
Wellington Management Company, LLP 175,616 0.32 -32,424 6/30/20
Acadian Asset Management LLC 169,756 0.31 9,491 6/30/20
Karrels (James) 152,460 0.28 4,473 3/20/20
MFS Investment Management 150,170 0.28 -3,826 6/30/20
Goldman Sachs Asset Management (US) 142,220 0.26 126,067 6/30/20
BNY Mellon Asset Management 128,067 0.24 6,064 6/30/20

* Insider values reflect direct beneficial ownership.

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