Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 188 758.82 92.90 38,420,972
Mutual Fund 221 379.81 39.03 16,141,178
Insider 8 9.94 1.07 441,877

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 91 125.00 15.05 6,224,671
Sellers 67 -58.15 7.38 -3,051,024
Net -- 66.85 7.67 3,173,647

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 758.82 92.90 38,420,972
Top 10 Inst. 465.56 56.04 23,176,912
Top 20 Inst. 605.45 73.89 30,559,185
Top 50 Inst. 717.85 87.87 36,344,265

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 42 129.34 16.46 6,805,975
Aggressive Growth 2 0.06 0.01 2,828
Core Growth 33 61.85 7.87 3,253,987
Growth 7 67.43 8.58 3,549,160
Income 4 10.99 1.39 576,201
Income Value 3 10.82 1.38 569,587
Yield 1 0.17 0.02 6,614
Index 21 120.25 15.29 6,323,615
Other 59 291.23 36.75 15,197,951
Broker Dealer 12 4.05 0.52 213,076
GARP 24 181.85 23.06 9,538,387
Hedge Fund 22 105.22 13.16 5,442,170
Specialty 1 0.11 0.01 4,318
Value 22 17.26 2.10 869,420
Core Value 17 14.23 1.73 717,488
Deep Value 5 3.03 0.37 151,932

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
OppenheimerFunds, Inc. 3,933,906 9.51 384,861 12/31/17
Fidelity Management & Research Company 3,639,537 8.80 -764,987 12/31/17
Boxer Capital, L.L.C. 3,177,426 7.68 977,426 2/14/18
Bellevue Asset Management AG 3,164,813 7.65 331,102 12/31/17
BlackRock Institutional Trust Company, N.A. 2,473,970 5.98 -34,205 12/31/17
Johnson & Johnson 1,923,077 4.65 -- 3/24/17
The Vanguard Group, Inc. 1,564,656 3.78 44,249 12/31/17
EcoR1 Capital, LLC 1,140,794 2.76 1,140,794 12/31/17
Point72 Asset Management, L.P. 1,084,417 2.62 -96,900 12/31/17
Interwest Venture Management Co 1,074,316 2.60 -- 3/31/18
State Street Global Advisors (US) 1,045,936 2.53 41,719 12/31/17
Wasatch Advisors, Inc. 1,028,443 2.49 -15,788 12/31/17
Koenig (Scott) 924,460 2.24 114,517 3/24/17
Pinnacle Associates Ltd. 816,975 1.98 -26,200 12/31/17
Aviva Holdings Ltd. 787,260 1.90 671,346 12/31/17
Hood River Capital Management LLC 632,521 1.53 43,722 12/31/17
Prosight Capital 607,696 1.47 607,696 12/31/17
Voya Investment Management LLC 577,181 1.40 74,036 12/31/17
Millennium Management LLC 482,301 1.17 415,262 12/31/17
Franklin Advisers, Inc. 479,500 1.16 -22,400 12/31/17
Columbia Wanger Asset Management, LLC 410,002 0.99 410,002 12/31/17
Northern Trust Investments, Inc. 388,355 0.94 -2,302 12/31/17
UBS Asset Management (Switzerland) 364,701 0.88 28,345 12/31/17
Baker Bros. Advisors LP 363,676 0.88 -- 12/31/17
Renaissance Technologies LLC 300,523 0.73 106,900 12/31/17
Rhenman & Partners Asset Management AB 300,000 0.73 -8,604 3/31/18
Geode Capital Management, L.L.C. 298,159 0.72 2,472 12/31/17
Dimensional Fund Advisors, L.P. 289,484 0.70 5,967 12/31/17
DekaBank Deutsche Girozentrale 228,500 0.55 20,000 9/30/17
Rock Springs Capital Management LP 225,000 0.54 -- 12/31/17
Deutsche Asset Management Americas 181,169 0.44 97,938 12/31/17
Granahan Investment Management, Inc. 175,398 0.42 175,398 12/31/17
Charles Schwab Investment Management, Inc. 175,106 0.42 6,118 12/31/17
E.Öhman J:or Fonder AB 165,349 0.40 20,300 12/31/17
Spark Investment Management LLC 154,600 0.37 -35,300 12/31/17
Bonvini Ezio 154,208 0.37 53,264 7/26/17
Dafna Capital Management, LLC 154,200 0.37 -- 12/31/17
Jacobs Levy Equity Management, Inc. 153,036 0.37 79,485 12/31/17
Eventide Asset Management, LLC 147,000 0.36 -- 12/31/17
Nuveen LLC 140,969 0.34 -271,195 12/31/17
Sphera Funds Management Ltd. 138,700 0.34 -70,000 12/31/17
BlackRock Investment Management, LLC 130,608 0.32 1,101 12/31/17
Tiger Management L.L.C. 127,967 0.31 -111,700 12/31/17
Karrels (James) 109,847 0.27 1,516 3/5/18
Invus Public Equities Advisors, LLC 100,000 0.24 -100,000 12/31/17
BNY Mellon Asset Management 90,023 0.22 -8,697 12/31/17
Columbia Threadneedle Investments (US) 84,894 0.21 84,894 12/31/17
Principal Global Investors (Equity) 83,606 0.20 -30,519 12/31/17
Candriam Belgium S.A. 75,000 0.18 -- 2/28/18
Candriam Luxembourg S.A. 75,000 0.18 75,000 12/31/17

* Insider values reflect direct beneficial ownership.

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