Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 210 835.32 95.10 46,413,777
Mutual Fund 400 401.49 50.70 24,031,440
Insider 11 28.06 3.19 1,559,187

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 122 236.37 26.89 13,123,109
Sellers 92 -129.33 15.83 -7,723,722
Net 107.04 11.06 5,399,387

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 888.23 102.28 49,920,914
Top 10 Inst. 448.41 52.14 25,447,852
Top 20 Inst. 618.85 71.56 34,927,509
Top 50 Inst. 801.41 92.37 45,081,076

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 49 171.43 19.48 9,509,607
Aggressive Growth 3 1.66 0.19 92,495
Core Growth 33 80.86 9.23 4,507,316
Growth 13 88.90 10.06 4,909,796
Income 7 12.35 1.41 687,067
Income Value 4 10.10 1.15 562,123
Yield 3 2.25 0.26 124,944
Index 23 165.32 18.84 9,196,235
Other 76 404.52 46.04 22,471,452
Broker Dealer 15 9.01 1.03 501,353
GARP 24 178.92 20.41 9,963,688
Hedge Fund 33 185.69 21.08 10,288,153
Specialty 1 0.77 0.09 42,613
VC Private Equity 3 30.13 3.43 1,675,645
Value 27 66.51 7.58 3,700,039
Core Value 23 60.47 6.89 3,364,204
Deep Value 4 6.04 0.69 335,835

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
OppenheimerFunds, Inc. 4,463,410 9.15 16,569 3/31/19
Bellevue Asset Management AG 4,190,305 8.59 -159,960 3/31/19
BlackRock Institutional Trust Company, N.A. 3,056,400 6.26 45,027 3/31/19
The Vanguard Group, Inc. 3,036,294 6.22 485,167 3/31/19
Millennium Management LLC 2,802,472 5.74 1,280,332 5/15/19
Johnson & Johnson 1,923,077 3.94 -- 12/31/18
Fidelity Management & Research Company 1,557,731 3.19 -504,900 3/31/19
Point72 Asset Management, L.P. 1,551,249 3.18 1,064,009 3/31/19
Hood River Capital Management LLC 1,443,196 2.96 764,646 3/31/19
State Street Global Advisors (US) 1,423,718 2.92 78,189 3/31/19
Wasatch Advisors, Inc. 1,291,513 2.65 246,536 3/31/19
Dimensional Fund Advisors, L.P. 1,133,757 2.32 325,556 3/31/19
Federated Global Investment Management Corp. 1,100,688 2.26 1,100,155 3/31/19
Koenig (Scott) 1,084,255 2.22 -- 3/22/19
InterWest Partners 1,074,316 2.20 -- 3/31/19
Rhenman & Partners Asset Management AB 967,186 1.98 425,000 3/31/19
Renaissance Technologies LLC 823,723 1.69 627,623 3/31/19
D. E. Shaw & Co., L.P. 673,243 1.38 652,694 3/31/19
Candriam Luxembourg S.A. 665,488 1.36 122,501 3/31/19
Candriam Belgium S.A. 665,488 1.36 120,500 3/31/19
Lord, Abbett & Co. LLC 643,870 1.32 643,870 3/31/19
Pinnacle Associates Ltd. 625,148 1.28 86,920 3/31/19
Citadel LLC 610,443 1.25 511,876 3/31/19
Nuveen LLC 597,321 1.22 355,076 3/31/19
Sofinnova Ventures, Inc. 523,756 1.07 190,835 3/31/19
Geode Capital Management, L.L.C. 507,664 1.04 51,790 3/31/19
Northern Trust Investments, Inc. 498,401 1.02 24,111 3/31/19
Eventide Asset Management, LLC 485,000 0.99 485,000 3/31/19
683 Capital Management LLC 484,970 0.99 100,000 3/31/19
Franklin Advisers, Inc. 459,335 0.94 -- 3/31/19
UBS Asset Management (Switzerland) 458,122 0.94 -61,947 3/31/19
Columbia Wanger Asset Management, LLC 315,971 0.65 -190,413 3/31/19
Baker Bros. Advisors LP 302,600 0.62 302,600 3/31/19
Rock Springs Capital Management LP 300,000 0.61 219,019 3/31/19
Rubric Capital Management LP 282,200 0.58 282,200 3/31/19
Numeric Investors LLC 262,586 0.54 73,000 3/31/19
Macquarie Investment Management 260,000 0.53 180,000 3/31/19
GMT Capital Corp. 255,200 0.52 255,200 3/31/19
Spark Investment Management LLC 240,400 0.49 -64,100 3/31/19
Charles Schwab Investment Management, Inc. 239,140 0.49 -5,532 3/31/19
Sphera Funds Management Ltd. 235,000 0.48 235,000 3/31/19
Granahan Investment Management, Inc. 227,719 0.47 -12,769 3/31/19
Bank of America Merrill Lynch (US) 219,104 0.45 194,885 3/31/19
HBK Investments, L.P. 194,442 0.40 171,043 3/31/19
Principal Global Investors (Equity) 182,880 0.37 24,219 3/31/19
Deutsche Asset Management Americas 167,550 0.34 165,594 3/31/19
Bonvini Ezio 154,208 0.32 -- 3/22/19
Arrowstreet Capital, Limited Partnership 143,385 0.29 4,695 3/31/19
Allianz Global Investors U.S. LLC 139,529 0.29 38,539 3/31/19
BlackRock Investment Management, LLC 137,623 0.28 1,943 3/31/19

* Insider values reflect direct beneficial ownership.

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