Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	188	900.75	108.07	52,837,257
Mutual Fund	407	469.64	57.97	28,281,425
Insider	11	28.06	3.19	1,559,187

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	96	211.20	25.45	12,445,472
Sellers	110	-178.28	21.02	-10,278,571
Net		32.92	4.43	2,166,901

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	873.08	106.07	51,863,458
Top 10 Inst.	470.67	57.72	28,219,086
Top 20 Inst.	637.40	77.68	37,979,918
Top 50 Inst.	807.42	98.23	48,030,061

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	44	166.14	19.94	9,749,336
Aggressive Growth	2	0.65	0.08	38,446
Core Growth	30	76.72	9.25	4,522,642
Growth	12	88.77	10.61	5,188,248
Income	6	3.98	0.48	235,812
Income Value	2	2.14	0.26	126,057
Yield	4	1.84	0.22	109,755
Index	23	200.31	24.25	11,855,124
Other	68	456.89	54.55	26,672,597
Broker Dealer	15	7.11	0.86	419,252
GARP	23	290.39	34.46	16,846,851
Hedge Fund	26	128.90	15.56	7,609,650
Specialty	1	0.69	0.08	40,512
VC Private Equity	3	29.80	3.59	1,756,332
Value	23	64.81	7.81	3,819,029
Core Value	19	59.65	7.19	3,514,901
Deep Value	4	5.16	0.62	304,128

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Invesco Advisers, Inc.	4,468,090	9.14	4,379,070	6/30/19
Bellevue Asset Management AG	4,395,264	8.99	204,959	6/30/19
BlackRock Institutional Trust Company, N.A.	3,567,837	7.30	511,437	6/30/19
The Vanguard Group, Inc.	3,198,214	6.54	161,920	6/30/19
Millennium Management LLC	2,946,050	6.03	143,578	6/30/19
State Street Global Advisors (US)	2,623,875	5.37	1,200,157	6/30/19
Columbia Wanger Asset Management, LLC	2,258,989	4.62	1,943,018	6/30/19
Johnson & Johnson	1,923,077	3.93	--	12/31/18
Wasatch Advisors, Inc.	1,422,245	2.91	130,732	6/30/19
Hood River Capital Management LLC	1,415,445	2.90	-27,751	6/30/19
Fidelity Management & Research Company	1,282,543	2.62	-275,188	6/30/19
Dimensional Fund Advisors, L.P.	1,262,543	2.58	128,786	6/30/19
Koenig (Scott)	1,084,255	2.22	--	3/22/19
InterWest Partners	1,074,316	2.20	--	6/30/19
GMT Capital Corp.	1,049,100	2.15	793,900	6/30/19
Rhenman & Partners Asset Management AB	857,169	1.75	-110,017	6/30/19
Federated Global Investment Management Corp.	849,807	1.74	-250,881	6/30/19
Nuveen LLC	799,123	1.63	201,802	6/30/19
Candriam Luxembourg S.A.	750,988	1.54	85,500	6/30/19
Candriam Belgium S.A.	750,988	1.54	--	6/30/19
Lord, Abbett & Co. LLC	741,191	1.52	97,321	6/30/19
UBS Asset Management (Switzerland)	698,966	1.43	240,844	6/30/19
Geode Capital Management, L.L.C.	598,129	1.22	90,465	6/30/19
Pinnacle Associates Ltd.	576,465	1.18	-48,683	6/30/19
Sofinnova Investments, Inc	550,443	1.13	26,687	6/30/19
683 Capital Management LLC	534,970	1.09	50,000	6/30/19
Northern Trust Investments, Inc.	504,754	1.03	6,353	6/30/19
Eventide Asset Management, LLC	485,000	0.99	--	6/30/19
Point72 Asset Management, L.P.	445,572	0.91	-1,105,677	6/30/19
Renaissance Technologies LLC	424,423	0.87	-399,300	6/30/19
Numeric Investors LLC	333,460	0.68	70,874	6/30/19
BlackRock Advisors (UK) Limited	319,370	0.65	7,215	7/31/19
BlackRock Asset Management Ireland Limited	318,953	0.65	305,333	6/30/19
PanAgora Asset Management Inc.	300,587	0.61	300,587	6/30/19
Rock Springs Capital Management LP	300,000	0.61	--	6/30/19
D. E. Shaw & Co., L.P.	298,438	0.61	-374,805	6/30/19
Macquarie Investment Management	275,000	0.56	15,000	6/30/19
Charles Schwab Investment Management, Inc.	262,919	0.54	23,779	6/30/19
BlackRock Financial Management, Inc.	240,646	0.49	105,342	6/30/19
Principal Global Investors (Equity)	234,832	0.48	51,952	6/30/19
Granahan Investment Management, Inc.	214,415	0.44	-13,304	6/30/19
Eversept Partners, LP	190,623	0.39	190,623	6/30/19
AXA Rosenberg Investment Management LLC	178,400	0.36	110,026	6/30/19
BlackRock Investment Management, LLC	174,647	0.36	37,024	6/30/19
Bonvini Ezio	154,208	0.32	--	3/22/19
Medical Strategy GmbH	149,055	0.30	--	6/30/19
Rafferty Asset Management LLC	142,918	0.29	93,157	6/30/19
Karrels (James)	135,487	0.28	--	3/22/19
Allianz Global Investors U.S. LLC	134,699	0.28	-4,830	6/30/19
Fosun International Ltd	131,573	0.27	54,000	6/30/19

* Insider values reflect direct beneficial ownership.