Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder Holders Value ($MM) % O/S Shares
Institution 207 1,375.48 97.30 54,687,565
Mutual Fund 279 427.68 32.08 18,012,587
Insider 9 12.73 2.84 1,596,249

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 109 114.91 8.13 4,571,605
Sellers 107 -215.69 14.34 -8,057,785
Net -100.79 6.20 -3,486,180

INSTITUTIONAL SHAREHOLDER CONCENTRATION

Value ($MM) % O/S Shares
Total Inst. 1,388.21 100.14 56,283,910
Top 10 Inst. 877.75 62.00 34,845,066
Top 20 Inst. 1,107.03 79.78 44,842,338
Top 50 Inst. 1,310.57 94.42 53,065,483

INSTITUTIONAL SHAREHOLDER STYLE

Holders Value ($MM) % Inst Shares Shares
Growth 54 256.59 18.15 10,202,404
Aggressive Growth 3 1.55 0.11 61,692
Core Growth 40 103.50 7.34 4,124,665
Growth 11 151.53 10.70 6,016,047
Income 5 3.89 0.28 158,855
Income Value 1 3.29 0.23 130,575
Yield 4 0.60 0.05 28,280
Index 28 311.06 22.04 12,386,876
Other 68 772.75 54.58 30,677,704
Broker Dealer 19 13.36 0.94 530,233
GARP 20 250.17 17.67 9,931,154
Hedge Fund 28 476.71 33.67 18,925,136
Specialty -- -- -- --
VC Private Equity 1 32.52 2.30 1,291,181
Value 26 19.07 1.35 760,615
Core Value 21 12.30 0.87 491,553
Deep Value 5 6.77 0.48 269,062

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder Shares Held % O/S Share Change Filing Date
Bellevue Asset Management AG 5,282,188 9.40 280,072 9/30/20
Invesco Advisers, Inc. 4,451,810 7.92 -1,884 9/30/20
RA Capital Management, LP 4,375,217 7.78 -209,435 9/30/20
BlackRock Institutional Trust Company, N.A. 3,839,080 6.83 154,665 9/30/20
Consonance Capital Management LP 3,747,298 6.67 -294,237 9/30/20
Point72 Asset Management, L.P. 3,595,079 6.40 915,176 9/30/20
The Vanguard Group, Inc. 3,300,787 5.87 18,903 9/30/20
Wasatch Global Investors Inc 2,433,724 4.33 122,142 9/30/20
State Street Global Advisors (US) 2,309,668 4.11 740,388 9/30/20
Great Point Partners, LLC 1,510,215 2.69 10,215 9/30/20
Dimensional Fund Advisors, L.P. 1,360,785 2.42 -6,541 9/30/20
Perceptive Advisors LLC 1,291,181 2.30 3,167 9/30/20
RTW Investments L.P. 1,255,299 2.23 9,483 9/30/20
Fidelity Management & Research Company LLC 1,169,553 2.08 686,201 9/30/20
Koenig (Scott) 1,164,150 2.07 79,895 3/20/20
Nuveen LLC 891,967 1.59 127,172 9/30/20
Geode Capital Management, L.L.C. 785,369 1.40 39,763 9/30/20
D. E. Shaw & Co., L.P. 729,464 1.30 -125,188 9/30/20
Hood River Capital Management LLC 678,178 1.21 -70,740 9/30/20
Millennium Management LLC 671,326 1.19 -511,495 9/30/20
Rhenman & Partners Asset Management AB 635,711 1.13 -39,289 9/30/20
Northern Trust Investments, Inc. 587,109 1.04 16,481 9/30/20
Candriam Belgium S.A. 581,854 1.04 113,421 9/30/20
Citadel Advisors LLC 572,575 1.02 250,096 9/30/20
Opaleye Management Inc. 527,000 0.94 26,000 9/30/20
Pinnacle Associates Ltd. 427,396 0.76 -95,910 9/30/20
Macquarie Investment Management 420,000 0.75 -- 9/30/20
BlackRock Financial Management, Inc. 379,577 0.68 110,708 9/30/20
Two Sigma Investments, LP 368,926 0.66 -6,376 9/30/20
Charles Schwab Investment Management, Inc. 350,075 0.62 27,210 9/30/20
BlackRock Advisors (UK) Limited 278,213 0.50 16,417 12/31/20
Rock Springs Capital Management LP 262,641 0.47 28,125 9/30/20
BlackRock Asset Management Ireland Limited 256,327 0.46 37,764 9/30/20
BlackRock Investment Management, LLC 204,729 0.36 5,449 9/30/20
PanAgora Asset Management Inc. 204,618 0.36 17,488 9/30/20
Atika Capital Management LLC 203,000 0.36 1,000 9/30/20
Principal Global Investors (Equity) 189,487 0.34 6,881 9/30/20
Granahan Investment Management, Inc. 183,875 0.33 -35,231 9/30/20
Arrowstreet Capital, Limited Partnership 180,658 0.32 -217,680 9/30/20
Wellington Management Company, LLP 170,541 0.30 -5,075 9/30/20
Goldman Sachs & Company, Inc. 162,307 0.29 -73,084 9/30/20
Karrels (James) 152,460 0.27 4,473 3/20/20
BofA Global Research (US) 144,112 0.26 20,046 9/30/20
BNY Mellon Asset Management 130,575 0.23 2,508 9/30/20
Goldman Sachs Asset Management (US) 121,410 0.22 -20,810 9/30/20
California Public Employees' Retirement System 119,488 0.21 22,488 9/30/20
MFS Investment Management 113,950 0.20 -36,220 9/30/20
Schweizerische Nationalbank 105,800 0.19 1,900 9/30/20
Endurant Capital Management LP 97,374 0.17 97,374 9/30/20
Bonvini Ezio 91,357 0.16 -62,851 9/18/20

* Insider values reflect direct beneficial ownership.

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