Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	221	1,254.98	97.16	54,697,312
Mutual Fund	286	432.96	30.97	17,396,394
Insider	7	49.81	2.63	1,563,902

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	119	153.33	11.13	6,674,791
Sellers	85	-173.59	12.53	-7,514,082
Net		-20.26	1.40	-839,291

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	1,304.79	99.80	56,261,214
Top 10 Inst.	747.50	58.12	32,699,004
Top 20 Inst.	997.45	76.62	43,174,967
Top 50 Inst.	1,212.49	92.94	52,379,395

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	53	212.85	16.56	9,316,674
Aggressive Growth	2	0.92	0.07	40,201
Core Growth	42	58.46	4.56	2,563,089
Growth	9	153.47	11.93	6,713,384
Income	5	3.93	0.30	167,999
Income Value	1	3.20	0.25	139,798
Yield	4	0.74	0.05	28,201
Index	33	344.32	26.39	14,877,377
Other	70	658.33	51.15	28,780,294
Broker Dealer	20	19.54	1.52	853,338
GARP	21	229.27	17.83	10,028,847
Hedge Fund	26	368.85	28.68	16,135,887
Specialty	1	1.35	0.07	42,355
VC Private Equity	2	39.32	3.06	1,719,867
Value	31	22.92	1.78	1,003,154
Core Value	27	16.49	1.28	722,240
Deep Value	4	6.43	0.50	280,914

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
Bellevue Asset Management AG	5,904,517	10.50	622,329	12/31/20
RA Capital Management, LP	4,375,217	7.78	--	12/31/20
BlackRock Institutional Trust Company, N.A.	4,176,444	7.42	337,364	12/31/20
Wasatch Global Investors Inc	3,672,416	6.53	1,238,692	12/31/20
The Vanguard Group, Inc.	3,575,584	6.36	274,797	12/31/20
Invesco Advisers, Inc.	3,016,240	5.36	-1,435,570	12/31/20
State Street Global Advisors (US)	2,577,363	4.58	267,695	12/31/20
Consonance Capital Management LP	2,299,829	4.09	-1,447,469	12/31/20
Citadel Advisors LLC	1,641,261	2.92	1,068,686	12/31/20
Point72 Asset Management, L.P.	1,460,133	2.60	-2,134,946	12/31/20
Perceptive Advisors LLC	1,261,060	2.24	-30,121	12/31/20
RTW Investments L.P.	1,256,409	2.23	1,110	12/31/20
Great Point Partners, LLC	1,239,287	2.20	-270,928	12/31/20
Dimensional Fund Advisors, L.P.	1,224,848	2.18	-135,937	12/31/20
Fidelity Management & Research Company LLC	1,205,850	2.14	36,297	12/31/20
Koenig (Scott)	1,164,150	1.94	--	3/19/21
Geode Capital Management, L.L.C.	884,669	1.57	99,300	12/31/20
Nuveen LLC	873,221	1.55	-18,746	12/31/20
Hood River Capital Management LLC	690,344	1.23	12,166	12/31/20
Candriam Belgium S.A.	676,125	1.20	94,271	12/31/20
Rhenman & Partners Asset Management AB	625,000	1.11	-10,711	12/31/20
Northern Trust Investments, Inc.	583,856	1.04	-3,253	12/31/20
Millennium Management LLC	580,580	1.03	-90,746	12/31/20
D. E. Shaw & Co., L.P.	567,404	1.01	-162,060	12/31/20
Sofinnova Investments, Inc	458,807	0.82	458,807	12/31/20
Two Sigma Investments, LP	453,568	0.81	84,642	12/31/20
Macquarie Investment Management	420,000	0.75	--	12/31/20
Charles Schwab Investment Management, Inc.	394,200	0.70	44,125	12/31/20
BlackRock Financial Management, Inc.	378,506	0.67	-1,071	12/31/20
BlackRock Advisors (UK) Limited	372,022	0.62	-833	3/31/21
Opaleye Management Inc.	370,600	0.66	-156,400	12/31/20
Goldman Sachs & Company, Inc.	364,171	0.65	201,864	12/31/20
Pinnacle Associates Ltd.	341,846	0.61	-85,550	12/31/20
PanAgora Asset Management Inc.	317,606	0.56	112,988	12/31/20
Rock Springs Capital Management LP	309,510	0.55	46,869	12/31/20
BlackRock Asset Management Ireland Limited	291,482	0.52	35,155	12/31/20
Granahan Investment Management, Inc.	289,861	0.52	105,986	12/31/20
Arrowstreet Capital, Limited Partnership	269,328	0.48	88,670	12/31/20
Baker Bros. Advisors LP	200,679	0.36	200,679	12/31/20
Principal Global Investors (Equity)	200,008	0.36	10,521	12/31/20
BlackRock Investment Management, LLC	192,121	0.34	-12,608	12/31/20
Atom Investors LP	157,452	0.28	114,723	12/31/20
BofA Global Research (US)	149,923	0.27	5,811	12/31/20
Wellington Management Company, LLP	149,796	0.27	-20,745	12/31/20
Karrels (James)	143,460	0.26	-15,000	3/22/21
BNY Mellon Asset Management	139,798	0.25	9,223	12/31/20
Tudor Investment Corporation	136,085	0.24	136,085	12/31/20
California Public Employees' Retirement System	117,741	0.21	-1,747	12/31/20
Schweizerische Nationalbank	116,200	0.21	10,400	12/31/20
MFS Investment Management	112,818	0.20	-1,132	12/31/20

* Insider values reflect direct beneficial ownership.