Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	209	1,043.99	98.47	41,556,414
Mutual Fund	245	383.39	39.15	16,521,645
Insider	8	9.94	1.05	441,877

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	107	145.82	13.81	5,826,743
Sellers	78	-65.37	6.86	-2,893,790
Net	--	80.45	6.95	2,932,953

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	1,043.99	98.47	41,556,414
Top 10 Inst.	592.92	55.84	23,566,143
Top 20 Inst.	803.52	75.68	31,936,572
Top 50 Inst.	966.10	90.99	38,398,074

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	47	166.31	15.72	6,632,920
Aggressive Growth	2	0.06	0.01	2,828
Core Growth	36	77.88	7.38	3,113,406
Growth	9	88.37	8.33	3,516,686
Income	6	14.68	1.38	584,284
Income Value	4	14.54	1.37	578,081
Yield	2	0.14	0.01	6,203
Index	21	162.10	15.27	6,445,799
Other	73	501.90	47.32	19,969,995
Broker Dealer	15	10.13	0.95	402,592
GARP	24	289.55	27.29	11,515,775
Hedge Fund	32	175.07	16.52	6,972,994
Specialty	1	0.11	0.01	4,318
VC/Private Equi	1	27.03	2.55	1,074,316
Value	22	21.61	2.04	861,386
Core Value	17	18.06	1.71	720,780
Deep Value	5	3.55	0.33	140,606

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
OppenheimerFunds, Inc.	3,949,370	9.36	15,464	3/31/18
Fidelity Management & Research Company	3,411,035	8.08	-228,502	3/31/18
Bellevue Asset Management AG	3,163,563	7.50	-1,250	3/31/18
BlackRock Institutional Trust Company, N.A.	2,435,861	5.77	-38,109	3/31/18
T. Rowe Price Associates, Inc.	2,258,991	5.35	2,250,691	3/31/18
Boxer Capital, L.L.C.	2,200,000	5.21	--	3/31/18
Johnson & Johnson	1,923,077	4.56	--	3/23/18
The Vanguard Group, Inc.	1,689,223	4.00	124,567	3/31/18
EcoR1 Capital, LLC	1,450,606	3.44	309,812	3/31/18
Point72 Asset Management, L.P.	1,084,417	2.57	--	3/31/18
InterWest Partners	1,074,316	2.55	--	3/31/18
State Street Global Advisors (US)	1,040,602	2.47	-5,334	3/31/18
Wasatch Advisors, Inc.	1,015,036	2.41	-13,407	3/31/18
Koenig (Scott)	1,004,358	2.38	79,898	3/23/18
Aviva Holdings Ltd.	977,426	2.32	190,166	3/31/18
Millennium Management LLC	897,982	2.13	415,681	3/31/18
Pinnacle Associates Ltd.	790,100	1.87	-26,875	3/31/18
Hood River Capital Management LLC	646,109	1.53	13,588	3/31/18
Franklin Advisers, Inc.	479,500	1.14	--	3/31/18
Prosight Capital	445,000	1.05	-162,696	3/31/18
Renaissance Technologies LLC	399,323	0.95	98,800	3/31/18
Northern Trust Investments, Inc.	389,505	0.92	1,150	3/31/18
Baker Bros. Advisors LP	363,676	0.86	--	3/31/18
Voya Investment Management LLC	363,433	0.86	-213,748	3/31/18
UBS Asset Management (Switzerland)	344,742	0.82	-19,959	3/31/18
Columbia Wanger Asset Management, LLC	336,728	0.80	-73,274	3/31/18
Geode Capital Management, L.L.C.	313,860	0.74	15,701	3/31/18
Rhenman & Partners Asset Management AB	300,000	0.71	-8,604	3/31/18
Dimensional Fund Advisors, L.P.	289,484	0.69	--	3/31/18
Rock Springs Capital Management LP	275,000	0.65	50,000	3/31/18
683 Capital Management LLC	250,000	0.59	250,000	3/31/18
Spark Investment Management LLC	226,000	0.54	71,400	3/31/18
Granahan Investment Management, Inc.	219,264	0.52	43,866	3/31/18
Monashee Investment Management, LLC	197,500	0.47	197,500	3/31/18
Victory Capital Management Inc.	176,600	0.42	176,600	3/31/18
Charles Schwab Investment Management, Inc.	174,463	0.41	-643	3/31/18
Morgan Stanley & Co. LLC	165,802	0.39	97,947	3/31/18
Bonvini Ezio	154,208	0.37	--	3/23/18
Alyeska Investment Group, L.P.	150,000	0.36	150,000	3/31/18
Deutsche Asset Management Americas	148,502	0.35	-32,667	3/31/18
Eventide Asset Management, LLC	147,000	0.35	--	3/31/18
Nuveen LLC	143,023	0.34	2,054	3/31/18
Jacobs Levy Equity Management, Inc.	137,497	0.33	-15,539	3/31/18
Sphera Funds Management Ltd.	135,000	0.32	-3,700	3/31/18
OxFORD Asset Management	129,715	0.31	129,715	3/31/18
BlackRock Investment Management, LLC	119,315	0.28	-11,293	3/31/18
Karrels (James)	114,847	0.27	6,516	3/23/18
Columbia Threadneedle Investments (US)	100,380	0.24	15,486	3/31/18
Citadel LLC	99,130	0.23	43,101	3/31/18
CVI Holdings LLC	97,505	0.23	97,505	3/31/18

* Insider values reflect direct beneficial ownership.