Ownership Profile

SHAREHOLDER BREAKDOWN

Shareholder	Holders	Value ($MM)	% O/S	Shares
Institution	205	531.07	84.79	41,361,343
Mutual Fund	283	322.51	45.99	22,435,009
Insider	8	8.58	1.12	545,069

INSTITUTIONAL SHAREHOLDER ROTATION

Shareholder	Holders	Value Chg ($MM)	% O/S	Share Change
Buyers	102	70.34	11.28	5,503,276
Sellers	83	-105.98	14.62	-7,129,953
Net	--	-35.64	3.34	-1,626,677

INSTITUTIONAL SHAREHOLDER CONCENTRATION

	Value ($MM)	% O/S	Shares
Total Inst.	531.07	84.79	41,361,343
Top 10 Inst.	305.14	49.43	24,109,802
Top 20 Inst.	390.92	63.36	30,904,800
Top 50 Inst.	481.31	77.38	37,748,185

INSTITUTIONAL SHAREHOLDER STYLE

	Holders	Value ($MM)	% Inst Shares	Shares
Growth	50	109.37	17.43	8,499,994
Aggressive Growth	3	2.32	0.38	182,996
Core Growth	36	44.01	7.10	3,462,655
Growth	11	63.04	9.95	4,854,343
Income	7	8.51	1.37	666,122
Income Value	4	7.13	1.15	561,764
Yield	3	1.37	0.21	104,358
Index	21	107.61	17.35	8,462,453
Other	66	230.78	37.30	18,194,394
Broker Dealer	12	2.99	0.48	235,377
GARP	20	149.92	24.28	11,846,143
Hedge Fund	29	44.74	7.22	3,522,680
Specialty	1	0.64	0.07	32,078
VC/Private Equi	4	32.49	5.24	2,558,116
Value	25	17.01	2.74	1,337,351
Core Value	20	14.03	2.26	1,102,833
Deep Value	5	2.98	0.48	234,518

TOP HOLDERS: INSTITUTIONAL INVESTOR

Holder	Shares Held	% O/S	Share Change	Filing Date
OppenheimerFunds, Inc.	4,446,841	9.12	359,061	12/31/18
Bellevue Asset Management AG	4,350,265	8.92	635,551	12/31/18
BlackRock Institutional Trust Company, N.A.	3,011,373	6.17	38,350	12/31/18
The Vanguard Group, Inc.	2,551,127	5.23	280,586	12/31/18
T. Rowe Price Associates, Inc.	2,250,287	4.61	-32,859	12/31/18
Fidelity Management & Research Company	2,062,631	4.23	-557,580	12/31/18
Johnson & Johnson	1,923,077	3.94	--	12/31/18
State Street Global Advisors (US)	1,345,529	2.76	106,414	12/31/18
Cohen Private Ventures, LLC	1,084,417	2.22	1,084,417	12/31/18
Koenig (Scott)	1,084,255	2.22	39,897	1/3/19
InterWest Partners	1,074,316	2.20	--	12/31/18
Wasatch Advisors, Inc.	1,044,977	2.14	-1,420	12/31/18
Dimensional Fund Advisors, L.P.	808,201	1.66	225,690	12/31/18
Hood River Capital Management LLC	678,550	1.39	9,910	12/31/18
Candriam Luxembourg S.A.	542,987	1.11	186,387	12/31/18
Rhenman & Partners Asset Management AB	542,186	1.11	200,600	12/31/18
Candriam Belgium S.A.	539,100	1.11	--	1/31/19
Pinnacle Associates Ltd.	538,228	1.10	-56,068	12/31/18
UBS Asset Management (Switzerland)	520,069	1.07	41,530	12/31/18
Columbia Wanger Asset Management, LLC	506,384	1.04	61,141	12/31/18
Point72 Asset Management, L.P.	487,240	1.00	-647,177	12/31/18
Northern Trust Investments, Inc.	474,290	0.97	-1,379	12/31/18
Franklin Advisers, Inc.	459,335	0.94	--	12/31/18
Geode Capital Management, L.L.C.	455,874	0.93	39,246	12/31/18
683 Capital Management LLC	384,970	0.79	49,336	12/31/18
Sofinnova Ventures, Inc.	332,921	0.68	332,921	12/31/18
Spark Investment Management LLC	304,500	0.62	15,800	12/31/18
Millennium Management LLC	257,680	0.53	30,622	12/31/18
Charles Schwab Investment Management, Inc.	244,672	0.50	-2,213	12/31/18
Nuveen LLC	242,245	0.50	-1,578	12/31/18
Granahan Investment Management, Inc.	240,488	0.49	-6,428	12/31/18
Renaissance Technologies LLC	196,100	0.40	37,077	12/31/18
Prosight Capital	194,129	0.40	-263,346	12/31/18
Arctic Fund Management AS	193,517	0.40	-85,890	9/30/18
Numeric Investors LLC	189,586	0.39	129,679	12/31/18
Voya Investment Management LLC	184,693	0.38	-728,285	12/31/18
BlackRock Financial Management, Inc.	180,788	0.37	96,659	12/31/18
OxFORD Asset Management	161,486	0.33	71,906	12/31/18
Principal Global Investors (Equity)	158,661	0.33	456	12/31/18
361 Capital LLC	154,717	0.32	154,717	12/31/18
Bonvini Ezio	154,208	0.32	53,264	3/23/18
Opaleye Management Inc.	150,000	0.31	150,000	12/31/18
Jacobs Levy Equity Management, Inc.	142,866	0.29	5,000	12/31/18
Goldman Sachs Asset Management (US)	142,679	0.29	35,837	12/31/18
Arrowstreet Capital, Limited Partnership	138,690	0.28	115,027	12/31/18
BlackRock Investment Management, LLC	135,680	0.28	4,197	12/31/18
Karrels (James)	135,487	0.28	12,640	1/24/19
Squarepoint Capital LLP	120,131	0.25	76,247	12/31/18
Columbia Threadneedle Investments (US)	117,213	0.24	11,307	12/31/18
Vident Investment Advisory, LLC	108,539	0.22	4,053	12/31/18

* Insider values reflect direct beneficial ownership.