| Bellevue Asset Management AG |
9,942,313 |
15.85 |
-23,549 |
6/30/24 |
| Armistice Capital LLC |
6,000,000 |
9.57 |
3,600,000 |
6/30/24 |
| BlackRock Institutional Trust Company, N.A. |
4,645,756 |
7.41 |
-145,122 |
6/30/24 |
| The Vanguard Group, Inc. |
4,125,041 |
6.58 |
457,641 |
6/30/24 |
| Millennium Management LLC |
3,312,672 |
5.28 |
607,956 |
6/30/24 |
| Frazier Life Sciences Management, L.P. |
3,010,727 |
4.80 |
539,023 |
6/30/24 |
| Wasatch Global Investors Inc |
2,451,797 |
3.91 |
1,462,218 |
6/30/24 |
| Two Sigma Investments, LP |
2,375,393 |
3.79 |
2,362,030 |
6/30/24 |
| RA Capital Management, LP |
2,082,021 |
3.32 |
-- |
6/30/24 |
| State Street Global Advisors (US) |
1,542,590 |
2.46 |
-2,847,057 |
6/30/24 |
| Geode Capital Management, L.L.C. |
1,415,239 |
2.26 |
-16,774 |
6/30/24 |
| Koenig (Scott) |
1,298,675 |
2.07 |
-- |
3/22/24 |
| T. Rowe Price Associates, Inc. |
1,295,804 |
2.07 |
-1,110,943 |
6/30/24 |
| Rock Springs Capital Management LP |
1,053,647 |
1.68 |
-251,603 |
6/30/24 |
| Hudson Bay Capital Management LP |
916,527 |
1.46 |
786,394 |
6/30/24 |
| Dimensional Fund Advisors, L.P. |
898,497 |
1.43 |
-152,762 |
6/30/24 |
| Vestal Point Capital, LP |
800,000 |
1.28 |
75,000 |
6/30/24 |
| PanAgora Asset Management Inc. |
741,490 |
1.18 |
278,060 |
6/30/24 |
| Marshall Wace LLP |
658,007 |
1.05 |
621,232 |
6/30/24 |
| Pinnacle Associates Ltd. |
637,319 |
1.02 |
-9,916 |
6/30/24 |
| Acadian Asset Management LLC |
586,079 |
0.93 |
112,666 |
6/30/24 |
| Charles Schwab Investment Management, Inc. |
510,505 |
0.81 |
-12,441 |
6/30/24 |
| Northern Trust Investments, Inc. |
487,500 |
0.78 |
-17,929 |
6/30/24 |
| Jane Street Capital, L.L.C. |
487,201 |
0.78 |
108,678 |
6/30/24 |
| Renaissance Technologies LLC |
484,027 |
0.77 |
-231,000 |
6/30/24 |
| Connor, Clark & Lunn Investment Management Ltd. |
475,056 |
0.76 |
56,774 |
6/30/24 |
| Macquarie Investment Management |
420,000 |
0.67 |
-- |
6/30/24 |
| Jacobs Levy Equity Management, Inc. |
418,890 |
0.67 |
270,872 |
6/30/24 |
| Goldman Sachs & Company, Inc. |
405,646 |
0.65 |
185,751 |
6/30/24 |
| BlackRock Financial Management, Inc. |
391,413 |
0.62 |
-117,235 |
6/30/24 |
| Morgan Stanley & Co. LLC |
373,681 |
0.60 |
242,363 |
6/30/24 |
| SilverArc Capital Management, LLC |
370,000 |
0.59 |
-108,079 |
6/30/24 |
| Woodline Partners LP |
369,542 |
0.59 |
4,117 |
6/30/24 |
| Principal Global Investors (Equity) |
348,421 |
0.56 |
3,818 |
6/30/24 |
| J.P. Morgan Securities LLC |
341,163 |
0.54 |
341,163 |
6/30/24 |
| Federated MDTA LLC |
300,499 |
0.48 |
-153,233 |
6/30/24 |
| Wellington Management Company, LLP |
265,407 |
0.42 |
19,576 |
6/30/24 |
| Northern Trust Global Investments |
223,140 |
0.36 |
-2,317 |
6/30/24 |
| Tang Capital Management, LLC |
218,856 |
0.35 |
218,856 |
6/30/24 |
| Walleye Capital LLC |
203,945 |
0.33 |
156,630 |
6/30/24 |
| Ikarian Capital LLC |
200,079 |
0.32 |
-118,088 |
6/30/24 |
| Nuveen LLC |
195,772 |
0.31 |
-350,693 |
6/30/24 |
| Karrels (James) |
171,452 |
0.27 |
-30,000 |
3/22/24 |
| TD Asset Management Inc. |
169,000 |
0.27 |
-44,448 |
6/30/24 |
| BlackRock Investment Management, LLC |
162,002 |
0.26 |
-1,783 |
6/30/24 |
| Ghost Tree Capital, LLC |
150,000 |
0.24 |
150,000 |
6/30/24 |
| Healthinvest Partners AB |
143,407 |
0.23 |
94,100 |
6/30/24 |
| AQR Capital Management, LLC |
143,161 |
0.23 |
61,131 |
6/30/24 |
| BNY Mellon Asset Management |
142,573 |
0.23 |
8,514 |
6/30/24 |
| BlackRock Advisors (UK) Limited |
134,680 |
0.21 |
2,077 |
7/31/24 |
