Press Release

 MacroGenics to Present Pre-Clinical Data on MGD006 at 26^th EORTC-NCI-AACR Symposium

ROCKVILLE, Md., October 30, 2014 - MacroGenics, Inc. (Nasdaq: MGNX), a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer, as well as autoimmune disorders and infectious diseases, today announced that it will present pre-clinical data on MGD006 in a poster session at the 26^th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics taking place in Barcelona, Spain on November 18-21, 2014.  MGD006 is a Dual-Affinity Re-Targeting (DART®) bi-specific antibody-based molecule that recognizes both CD123 and CD3 and is being developed for the treatment of hematological malignancies.

The details of the presentation are as follows:

Session: Immunotherapy (Immune checkpoints, Vaccination, Oncolytic viruses, Cytokines)

Date: November 19, 2014

Poster Board Number: 132

Abstract Number in Proceedings Book: 138

Poster Viewing Session: 7:45 am - 8:00 pm, Poster # 132

Location: Exhibition Hall

Title: "Preclinical activity and safety of MGD006, a CD123 x CD3 Bispecific DART® molecule for the treatment of hematological malignancies"

About MGD006

MGD006 is a humanized DART molecule that recognizes both CD123 and CD3. The molecule was designed to redirect T cells via their CD3 component to kill CD123-expressing cells, as shown pre-clinically. CD123, the Interleukin-3 receptor alpha chain, has been reported to be overexpressed on malignant cells in a wide range of hematological malignancies including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).  AML and MDS are thought to arise from a small population of leukemic stem cells (LSCs) that generally resist conventional chemotherapeutic agents.  LSCs are characterized by high levels of CD123 expression that is low or absent in the corresponding normal hematopoietic stem cell population.  This product candidate is currently being tested in a Phase 1 clinical study in patients with relapsed or refractory AML.

About MacroGenics, Inc.

MacroGenics is a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer, as well as autoimmune disorders and infectious diseases. The Company generates its pipeline of product candidates from its proprietary suite of next-generation antibody-based technology platforms.  The combination of MacroGenics' technology platforms and protein engineering expertise has allowed the Company to generate promising product candidates and enter into several strategic collaborations with global pharmaceutical and biotechnology companies.  For more information, please see the Company's website at www.macrogenics.com.  MacroGenics and DART are registered trademarks of MacroGenics, Inc.

Cautionary Note on Forward-Looking Statements

Any statements in this press release about future expectations, plans and prospects for the Company, including statements about the Company's strategy, future operations, clinical development of the Company's therapeutic candidates, milestone or opt-in payments from the Company's collaborators, the Company's anticipated milestones and future expectations and plans and prospects for the Company and other statements containing the words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties inherent in the initiation and enrollment of future clinical trials, expectations of expanding ongoing clinical trials, availability and timing of data from ongoing clinical trials, expectations for regulatory approvals, other matters that could affect the availability or commercial potential of the Company's product candidates and other risk factors described in the Company's filings  with the Securities and Exchange Commission, including those discussed in the "Risk Factors" section of the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 20, 2014.  In addition, the forward-looking statements included in this press release represent the Company's views as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof.

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Contacts:

Jim Karrels, Vice President, CFO
MacroGenics, Inc.

1-301-251-5172, info@macrogenics.com

Karen Sharma, Vice President
MacDougall Biomedical Communications

1-781-235-3060, ksharma@macbiocom.com

CONTACT: Jim Karrels, Vice President, CFO

         MacroGenics, Inc.

         1-301-251-5172, info@macrogenics.com



         Karen Sharma, Vice President

         MacDougall Biomedical Communications

         1-781-235-3060, ksharma@macbiocom.com

Source: MacroGenics, Inc.

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